Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan
Abstract Background and Aim Acute pancreatitis (AP) is a rare extraintestinal manifestation of inflammatory bowel disease (IBD). Several studies from Western countries have reported that the severity of AP in patients with IBD is similar to that in the general population; however, its severity in pa...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12849 |
| _version_ | 1811177094435045376 |
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| author | Rintaro Moroi Kunio Tarasawa Mio Ikeda Ryotaro Matsumoto Yusuke Shimoyama Takeo Naito Tetsuya Takikawa Hisashi Shiga Shin Hamada Yoichi Kakuta Kazuhiro Kikuta Kiyohide Fushimi Kenji Fujimori Yoshitaka Kinouchi Atsushi Masamune |
| author_facet | Rintaro Moroi Kunio Tarasawa Mio Ikeda Ryotaro Matsumoto Yusuke Shimoyama Takeo Naito Tetsuya Takikawa Hisashi Shiga Shin Hamada Yoichi Kakuta Kazuhiro Kikuta Kiyohide Fushimi Kenji Fujimori Yoshitaka Kinouchi Atsushi Masamune |
| author_sort | Rintaro Moroi |
| collection | DOAJ |
| description | Abstract Background and Aim Acute pancreatitis (AP) is a rare extraintestinal manifestation of inflammatory bowel disease (IBD). Several studies from Western countries have reported that the severity of AP in patients with IBD is similar to that in the general population; however, its severity in patients from Eastern countries in the era of biologics remains unclear. This study aimed to investigate the severity of AP in patients with IBD and the effect of biologics on the severity of AP using a nationwide database. Methods We divided 1138 eligible AP admissions from the Diagnosis Procedure Combination database system into IBD and non‐IBD groups after propensity score matching, and compared the severity of AP. We divided the IBD group into ulcerative colitis (UC) and Crohn's disease (CD) subgroups and compared each with the non‐IBD group. Logistic regression analysis was conducted to identify the clinical factors affecting acute pancreatitis. Results IBD and UC groups had lower rate of severe AP compared to the non‐IBD group (13.7% vs 28.3%, P < 0.0001 and 11.0% vs 28.3%, P < 0.0001, respectively). There were no differences in the rates of severe AP between the CD and non‐IBD groups. Multivariate analysis showed that biologics did not affect the severity of AP. Conclusion The severity of AP in patients with IBD may be lower than that in the general population; biologics for IBD may not worsen its severity. Further prospective studies are required to clarify the severity of AP in patients with IBD. |
| first_indexed | 2024-04-10T22:56:15Z |
| format | Article |
| id | doaj.art-ceeb8c53bc9346a5a3a951f463d9b01d |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-04-10T22:56:15Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-ceeb8c53bc9346a5a3a951f463d9b01d2023-01-14T11:33:20ZengWileyJGH Open2397-90702023-01-0171404710.1002/jgh3.12849Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in JapanRintaro Moroi0Kunio Tarasawa1Mio Ikeda2Ryotaro Matsumoto3Yusuke Shimoyama4Takeo Naito5Tetsuya Takikawa6Hisashi Shiga7Shin Hamada8Yoichi Kakuta9Kazuhiro Kikuta10Kiyohide Fushimi11Kenji Fujimori12Yoshitaka Kinouchi13Atsushi Masamune14Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Health Administration and Policy Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Health Policy and Informatics Tokyo Medical and Dental University Graduate School of Medicine Bunkyo‐ku Tokyo JapanDepartment of Health Administration and Policy Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanDivision of Gastroenterology Tohoku University Graduate School of Medicine Sendai JapanAbstract Background and Aim Acute pancreatitis (AP) is a rare extraintestinal manifestation of inflammatory bowel disease (IBD). Several studies from Western countries have reported that the severity of AP in patients with IBD is similar to that in the general population; however, its severity in patients from Eastern countries in the era of biologics remains unclear. This study aimed to investigate the severity of AP in patients with IBD and the effect of biologics on the severity of AP using a nationwide database. Methods We divided 1138 eligible AP admissions from the Diagnosis Procedure Combination database system into IBD and non‐IBD groups after propensity score matching, and compared the severity of AP. We divided the IBD group into ulcerative colitis (UC) and Crohn's disease (CD) subgroups and compared each with the non‐IBD group. Logistic regression analysis was conducted to identify the clinical factors affecting acute pancreatitis. Results IBD and UC groups had lower rate of severe AP compared to the non‐IBD group (13.7% vs 28.3%, P < 0.0001 and 11.0% vs 28.3%, P < 0.0001, respectively). There were no differences in the rates of severe AP between the CD and non‐IBD groups. Multivariate analysis showed that biologics did not affect the severity of AP. Conclusion The severity of AP in patients with IBD may be lower than that in the general population; biologics for IBD may not worsen its severity. Further prospective studies are required to clarify the severity of AP in patients with IBD.https://doi.org/10.1002/jgh3.12849acute pancreatitisbiologicsCrohn's diseaseinflammatory bowel diseaseulcerative colitis |
| spellingShingle | Rintaro Moroi Kunio Tarasawa Mio Ikeda Ryotaro Matsumoto Yusuke Shimoyama Takeo Naito Tetsuya Takikawa Hisashi Shiga Shin Hamada Yoichi Kakuta Kazuhiro Kikuta Kiyohide Fushimi Kenji Fujimori Yoshitaka Kinouchi Atsushi Masamune Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan JGH Open acute pancreatitis biologics Crohn's disease inflammatory bowel disease ulcerative colitis |
| title | Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan |
| title_full | Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan |
| title_fullStr | Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan |
| title_full_unstemmed | Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan |
| title_short | Severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics: A propensity‐score‐matched analysis using a nationwide database in Japan |
| title_sort | severity of acute pancreatitis in patients with inflammatory bowel disease in the era of biologics a propensity score matched analysis using a nationwide database in japan |
| topic | acute pancreatitis biologics Crohn's disease inflammatory bowel disease ulcerative colitis |
| url | https://doi.org/10.1002/jgh3.12849 |
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