Metabolic Regulation of Cardiac Regeneration
The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.933060/full |
| _version_ | 1828337319434780672 |
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| author | Xuewen Duan Xingguang Liu Zhenzhen Zhan |
| author_facet | Xuewen Duan Xingguang Liu Zhenzhen Zhan |
| author_sort | Xuewen Duan |
| collection | DOAJ |
| description | The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure. The hearts of adult mammals can hardly regenerate after cardiac injury since adult cardiomyocytes exit the cell cycle. Nonetheless, the hearts of early neonatal mammals possess a stronger capacity for regeneration. To improve the prognosis of patients with heart failure and to find the effective therapeutic strategies for it, it is essential to promote endogenous regeneration of adult mammalian cardiomyocytes. Mitochondrial metabolism maintains normal physiological functions of the heart and compensates for heart failure. In recent decades, the focus is on the changes in myocardial energy metabolism, including glucose, fatty acid, and amino acid metabolism, in cardiac physiological and pathological states. In addition to being a source of energy, metabolites are becoming key regulators of gene expression and epigenetic patterns, which may affect heart regeneration. However, the myocardial energy metabolism during heart regeneration is majorly unknown. This review focuses on the role of energy metabolism in cardiac regeneration, intending to shed light on the strategies for manipulating heart regeneration and promoting heart repair after cardiac injury. |
| first_indexed | 2024-04-13T22:13:45Z |
| format | Article |
| id | doaj.art-ceeba3db9aae4cbcb4d0c57f3fae3a9a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T22:13:45Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ceeba3db9aae4cbcb4d0c57f3fae3a9a2022-12-22T02:27:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.933060933060Metabolic Regulation of Cardiac RegenerationXuewen Duan0Xingguang Liu1Zhenzhen Zhan2Key Laboratory of Arrhythmias of the Ministry of Education of China, Institute of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Pathogen Biology, Naval Medical University, Shanghai, ChinaKey Laboratory of Arrhythmias of the Ministry of Education of China, Institute of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaThe mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure. The hearts of adult mammals can hardly regenerate after cardiac injury since adult cardiomyocytes exit the cell cycle. Nonetheless, the hearts of early neonatal mammals possess a stronger capacity for regeneration. To improve the prognosis of patients with heart failure and to find the effective therapeutic strategies for it, it is essential to promote endogenous regeneration of adult mammalian cardiomyocytes. Mitochondrial metabolism maintains normal physiological functions of the heart and compensates for heart failure. In recent decades, the focus is on the changes in myocardial energy metabolism, including glucose, fatty acid, and amino acid metabolism, in cardiac physiological and pathological states. In addition to being a source of energy, metabolites are becoming key regulators of gene expression and epigenetic patterns, which may affect heart regeneration. However, the myocardial energy metabolism during heart regeneration is majorly unknown. This review focuses on the role of energy metabolism in cardiac regeneration, intending to shed light on the strategies for manipulating heart regeneration and promoting heart repair after cardiac injury.https://www.frontiersin.org/articles/10.3389/fcvm.2022.933060/fullheart regenerationcardiomyocyte proliferationfatty acid metabolismglucose metabolismamino acid metabolismmetabolism regulation |
| spellingShingle | Xuewen Duan Xingguang Liu Zhenzhen Zhan Metabolic Regulation of Cardiac Regeneration Frontiers in Cardiovascular Medicine heart regeneration cardiomyocyte proliferation fatty acid metabolism glucose metabolism amino acid metabolism metabolism regulation |
| title | Metabolic Regulation of Cardiac Regeneration |
| title_full | Metabolic Regulation of Cardiac Regeneration |
| title_fullStr | Metabolic Regulation of Cardiac Regeneration |
| title_full_unstemmed | Metabolic Regulation of Cardiac Regeneration |
| title_short | Metabolic Regulation of Cardiac Regeneration |
| title_sort | metabolic regulation of cardiac regeneration |
| topic | heart regeneration cardiomyocyte proliferation fatty acid metabolism glucose metabolism amino acid metabolism metabolism regulation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.933060/full |
| work_keys_str_mv | AT xuewenduan metabolicregulationofcardiacregeneration AT xingguangliu metabolicregulationofcardiacregeneration AT zhenzhenzhan metabolicregulationofcardiacregeneration |