Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today?
A generation ago, the molecular properties of tumor cells were the focus of scientific interest in oncology research. Since then, it has become increasingly apparent that the tumor environment (TEM), whose major components are non-neoplastic cell types, is also of utmost importance for our understan...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/14 |
| _version_ | 1827369822747361280 |
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| author | Reinhold Nafe Elke Hattingen |
| author_facet | Reinhold Nafe Elke Hattingen |
| author_sort | Reinhold Nafe |
| collection | DOAJ |
| description | A generation ago, the molecular properties of tumor cells were the focus of scientific interest in oncology research. Since then, it has become increasingly apparent that the tumor environment (TEM), whose major components are non-neoplastic cell types, is also of utmost importance for our understanding of tumor growth, maintenance and resistance. In this review, we present the current knowledge concerning all cellular components within the TEM in gliomas, focusing on their molecular properties, expression patterns and influence on the biological behavior of gliomas. Insight into the TEM of gliomas has expanded considerably in recent years, including many aspects that previously received only marginal attention, such as the phenomenon of phagocytosis of glioma cells by macrophages and the role of the thyroid-stimulating hormone on glioma growth. We also discuss other topics such as the migration of lymphocytes into the tumor, phenotypic similarities between chemoresistant glioma cells and stem cells, and new clinical approaches with immunotherapies involving the cells of TEM. |
| first_indexed | 2024-03-08T09:58:11Z |
| format | Article |
| id | doaj.art-ceecf8d72483497eb4fa3e348cb3be2d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:58:11Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ceecf8d72483497eb4fa3e348cb3be2d2024-01-29T13:46:29ZengMDPI AGBiomedicines2227-90592023-12-011211410.3390/biomedicines12010014Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today?Reinhold Nafe0Elke Hattingen1Department of Neuroradiology, Clinics of Johann Wolfgang Goethe-University, Schleusenweg 2-16, D-60528 Frankfurt am Main, GermanyDepartment of Neuroradiology, Clinics of Johann Wolfgang Goethe-University, Schleusenweg 2-16, D-60528 Frankfurt am Main, GermanyA generation ago, the molecular properties of tumor cells were the focus of scientific interest in oncology research. Since then, it has become increasingly apparent that the tumor environment (TEM), whose major components are non-neoplastic cell types, is also of utmost importance for our understanding of tumor growth, maintenance and resistance. In this review, we present the current knowledge concerning all cellular components within the TEM in gliomas, focusing on their molecular properties, expression patterns and influence on the biological behavior of gliomas. Insight into the TEM of gliomas has expanded considerably in recent years, including many aspects that previously received only marginal attention, such as the phenomenon of phagocytosis of glioma cells by macrophages and the role of the thyroid-stimulating hormone on glioma growth. We also discuss other topics such as the migration of lymphocytes into the tumor, phenotypic similarities between chemoresistant glioma cells and stem cells, and new clinical approaches with immunotherapies involving the cells of TEM.https://www.mdpi.com/2227-9059/12/1/14gliomastumor environmentlymphocytestumor-associated macrophagesmyeloid-derived suppressor cellsdendritic cells |
| spellingShingle | Reinhold Nafe Elke Hattingen Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? Biomedicines gliomas tumor environment lymphocytes tumor-associated macrophages myeloid-derived suppressor cells dendritic cells |
| title | Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? |
| title_full | Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? |
| title_fullStr | Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? |
| title_full_unstemmed | Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? |
| title_short | Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today? |
| title_sort | cellular components of the tumor environment in gliomas what do we know today |
| topic | gliomas tumor environment lymphocytes tumor-associated macrophages myeloid-derived suppressor cells dendritic cells |
| url | https://www.mdpi.com/2227-9059/12/1/14 |
| work_keys_str_mv | AT reinholdnafe cellularcomponentsofthetumorenvironmentingliomaswhatdoweknowtoday AT elkehattingen cellularcomponentsofthetumorenvironmentingliomaswhatdoweknowtoday |