Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are considered the first line treatment for a subset of EGFR-mutated non-small cell lung cancer (NSCLC) patients. Although transformation to small cell lung cancer (SCLC) is one of the known mechanisms of resistanc...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2016-07-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2016-04-19.pdf |
| _version_ | 1819204136645689344 |
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| author | Soomin Ahn Soo Hyun Hwang Joungho Han Yoon-La Choi Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Woong-Yang Park |
| author_facet | Soomin Ahn Soo Hyun Hwang Joungho Han Yoon-La Choi Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Woong-Yang Park |
| author_sort | Soomin Ahn |
| collection | DOAJ |
| description | Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are considered the first line treatment for a subset of EGFR-mutated non-small cell lung cancer (NSCLC) patients. Although transformation to small cell lung cancer (SCLC) is one of the known mechanisms of resistance to EGFR TKIs, it is not certain whether transformation to SCLC is exclusively found as a mechanism of TKI resistance in EGFR-mutant tumors. Methods: We identified six patients with primary lung adenocarcinoma that showed transformation to SCLC on second biopsy (n = 401) during a 6-year period. Clinicopathologic information was analyzed and EGFR mutation results were compared between initial and second biopsy samples. Results: Six patients showed transformation from adenocarcinoma to SCLC, of which four were pure SCLCs and two were combined adenocarcinoma and SCLCs. Clinically, four cases were EGFR-mutant tumors from non-smoking females who underwent TKI treatment, and the EGFR mutation was retained in the transformed SCLC tumors. The remaining two adenocarcinomas were EGFR wild-type, and one of these patients received EGFR TKI treatment. Conclusions: NSCLC can acquire a neuroendocrine phenotype with or without EGFR TKI treatment. |
| first_indexed | 2024-12-23T04:31:01Z |
| format | Article |
| id | doaj.art-ceefb291f0a54166984ab34c39631e15 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-23T04:31:01Z |
| publishDate | 2016-07-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-ceefb291f0a54166984ab34c39631e152022-12-21T18:00:02ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452016-07-0150425826310.4132/jptm.2016.04.1916610Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six CasesSoomin Ahn0Soo Hyun Hwang1Joungho Han2Yoon-La Choi3Se-Hoon Lee4Jin Seok Ahn5Keunchil Park6Myung-Ju Ahn7Woong-Yang Park8 Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are considered the first line treatment for a subset of EGFR-mutated non-small cell lung cancer (NSCLC) patients. Although transformation to small cell lung cancer (SCLC) is one of the known mechanisms of resistance to EGFR TKIs, it is not certain whether transformation to SCLC is exclusively found as a mechanism of TKI resistance in EGFR-mutant tumors. Methods: We identified six patients with primary lung adenocarcinoma that showed transformation to SCLC on second biopsy (n = 401) during a 6-year period. Clinicopathologic information was analyzed and EGFR mutation results were compared between initial and second biopsy samples. Results: Six patients showed transformation from adenocarcinoma to SCLC, of which four were pure SCLCs and two were combined adenocarcinoma and SCLCs. Clinically, four cases were EGFR-mutant tumors from non-smoking females who underwent TKI treatment, and the EGFR mutation was retained in the transformed SCLC tumors. The remaining two adenocarcinomas were EGFR wild-type, and one of these patients received EGFR TKI treatment. Conclusions: NSCLC can acquire a neuroendocrine phenotype with or without EGFR TKI treatment.http://www.jpatholtm.org/upload/pdf/jptm-2016-04-19.pdfLung neoplasmsReceptor, epidermal growth factorTyrosine kinase inhibitorSmall cell lung carcinomaAdenocarcinoma |
| spellingShingle | Soomin Ahn Soo Hyun Hwang Joungho Han Yoon-La Choi Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Woong-Yang Park Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases Journal of Pathology and Translational Medicine Lung neoplasms Receptor, epidermal growth factor Tyrosine kinase inhibitor Small cell lung carcinoma Adenocarcinoma |
| title | Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases |
| title_full | Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases |
| title_fullStr | Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases |
| title_full_unstemmed | Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases |
| title_short | Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases |
| title_sort | transformation to small cell lung cancer of pulmonary adenocarcinoma clinicopathologic analysis of six cases |
| topic | Lung neoplasms Receptor, epidermal growth factor Tyrosine kinase inhibitor Small cell lung carcinoma Adenocarcinoma |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2016-04-19.pdf |
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