Thrombotic thrombocytopenic purpura: a case report
ABSTRACT Thrombocytopenic thrombotic purpura (TTP) is a severe hemorrhagic syndrome characterized by thrombocytopenia, microangiopathic hemolytic anemia and microvascular occlusion, besides the associated symptoms that may or may not be present: fever, neurological and renal impairment. The pathophy...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2018-07-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/jbpml/v54n4/1676-2444-jbpml-54-04-0255.pdf |
| _version_ | 1798026460433219584 |
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| author | João Paulo N. Drumond Rima M. Abou-Arabi Raissa P. C. Figueiredo Vanessa N. Mourão Juliana B. Aiziro Décio N. Caly Afonso José P. Cortez |
| author_facet | João Paulo N. Drumond Rima M. Abou-Arabi Raissa P. C. Figueiredo Vanessa N. Mourão Juliana B. Aiziro Décio N. Caly Afonso José P. Cortez |
| author_sort | João Paulo N. Drumond |
| collection | DOAJ |
| description | ABSTRACT Thrombocytopenic thrombotic purpura (TTP) is a severe hemorrhagic syndrome characterized by thrombocytopenia, microangiopathic hemolytic anemia and microvascular occlusion, besides the associated symptoms that may or may not be present: fever, neurological and renal impairment. The pathophysiology involves the autoimmune or genetic deficiency of a metalloproteinases activity (ADAMTS-13), responsible for the von Willebrand Factor cleavage. The treatment is based on plasmapheresis; and in acute or recurrent cases, corticosteroids and immunosuppressants are associated. In this article, we will discuss a case report about this disease, initially treated in the Emergency Room and followed in the Intensive Care Unit of a public reference hospital in São Paulo city, Brazil. All clinical diagnostic criteria were completely filled, facilitating the therapeutic approach of the patient. The report evidences that rapid intervention when made early diagnosis evolves with a good prognosis, and this pathology must be present as a differential diagnosis in the medical routine. |
| first_indexed | 2024-04-11T18:35:52Z |
| format | Article |
| id | doaj.art-ceefbdef8eb54bab80e67a97f01a748c |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-04-11T18:35:52Z |
| publishDate | 2018-07-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-ceefbdef8eb54bab80e67a97f01a748c2022-12-22T04:09:18ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742018-07-0154425525910.5935/1676-2444.20180045Thrombotic thrombocytopenic purpura: a case reportJoão Paulo N. DrumondRima M. Abou-ArabiRaissa P. C. FigueiredoVanessa N. MourãoJuliana B. AiziroDécio N. CalyAfonso José P. CortezABSTRACT Thrombocytopenic thrombotic purpura (TTP) is a severe hemorrhagic syndrome characterized by thrombocytopenia, microangiopathic hemolytic anemia and microvascular occlusion, besides the associated symptoms that may or may not be present: fever, neurological and renal impairment. The pathophysiology involves the autoimmune or genetic deficiency of a metalloproteinases activity (ADAMTS-13), responsible for the von Willebrand Factor cleavage. The treatment is based on plasmapheresis; and in acute or recurrent cases, corticosteroids and immunosuppressants are associated. In this article, we will discuss a case report about this disease, initially treated in the Emergency Room and followed in the Intensive Care Unit of a public reference hospital in São Paulo city, Brazil. All clinical diagnostic criteria were completely filled, facilitating the therapeutic approach of the patient. The report evidences that rapid intervention when made early diagnosis evolves with a good prognosis, and this pathology must be present as a differential diagnosis in the medical routine.http://www.scielo.br/pdf/jbpml/v54n4/1676-2444-jbpml-54-04-0255.pdfpurpura thrombotic thrombocytopenicanemia hemolyticplasmapheresis |
| spellingShingle | João Paulo N. Drumond Rima M. Abou-Arabi Raissa P. C. Figueiredo Vanessa N. Mourão Juliana B. Aiziro Décio N. Caly Afonso José P. Cortez Thrombotic thrombocytopenic purpura: a case report Jornal Brasileiro de Patologia e Medicina Laboratorial purpura thrombotic thrombocytopenic anemia hemolytic plasmapheresis |
| title | Thrombotic thrombocytopenic purpura: a case report |
| title_full | Thrombotic thrombocytopenic purpura: a case report |
| title_fullStr | Thrombotic thrombocytopenic purpura: a case report |
| title_full_unstemmed | Thrombotic thrombocytopenic purpura: a case report |
| title_short | Thrombotic thrombocytopenic purpura: a case report |
| title_sort | thrombotic thrombocytopenic purpura a case report |
| topic | purpura thrombotic thrombocytopenic anemia hemolytic plasmapheresis |
| url | http://www.scielo.br/pdf/jbpml/v54n4/1676-2444-jbpml-54-04-0255.pdf |
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