A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics
<p>Abstract</p> <p>Objectives</p> <p>We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features.</p> <p>Design and Methods</p> <p>Concentrations of human Aβ (1-42...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-01-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/8/1/4 |
| _version_ | 1818661776689987584 |
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| author | Al- Ayadhi Laila Y Ben Bacha Abir G Kotb Malak El-Ansary Afaf K |
| author_facet | Al- Ayadhi Laila Y Ben Bacha Abir G Kotb Malak El-Ansary Afaf K |
| author_sort | Al- Ayadhi Laila Y |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objectives</p> <p>We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features.</p> <p>Design and Methods</p> <p>Concentrations of human Aβ (1-42), Aβ (1-40), and Aβ (40/42) in the plasma of 52 autistic children (aged 3-16 years) and 36 age-matched control subjects were determined by using the ELISA technique and were compared.</p> <p>Results</p> <p>Compared to control subjects, autistic children exhibited significantly lower concentrations of both Aβ (1-40) and Aβ (1-42) <b/>and lower Aβ (40/42) concentration ratio. Receiver operating characteristics curve (ROC) analysis showed that these measurements of Aβ peptides showed high specificity and sensitivity in distinguishing autistic children from control subjects.</p> <p>Conclusions</p> <p>Lower concentrations of Aβ (1-42) and Aβ (1-40) were attributed to loss of Aβ equilibrium between the <b/>brain and blood, an imbalance that may lead to failure to draw Aβ from the brain and/or impairment of β- and γ- secretase's concentration or kinetics as enzymes involving in Aβ production.</p> |
| first_indexed | 2024-12-17T04:50:26Z |
| format | Article |
| id | doaj.art-cef20cb9b4e843baa0301880260b2deb |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-17T04:50:26Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-cef20cb9b4e843baa0301880260b2deb2022-12-21T22:02:56ZengBMCBehavioral and Brain Functions1744-90812012-01-0181410.1186/1744-9081-8-4A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autisticsAl- Ayadhi Laila YBen Bacha Abir GKotb MalakEl-Ansary Afaf K<p>Abstract</p> <p>Objectives</p> <p>We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features.</p> <p>Design and Methods</p> <p>Concentrations of human Aβ (1-42), Aβ (1-40), and Aβ (40/42) in the plasma of 52 autistic children (aged 3-16 years) and 36 age-matched control subjects were determined by using the ELISA technique and were compared.</p> <p>Results</p> <p>Compared to control subjects, autistic children exhibited significantly lower concentrations of both Aβ (1-40) and Aβ (1-42) <b/>and lower Aβ (40/42) concentration ratio. Receiver operating characteristics curve (ROC) analysis showed that these measurements of Aβ peptides showed high specificity and sensitivity in distinguishing autistic children from control subjects.</p> <p>Conclusions</p> <p>Lower concentrations of Aβ (1-42) and Aβ (1-40) were attributed to loss of Aβ equilibrium between the <b/>brain and blood, an imbalance that may lead to failure to draw Aβ from the brain and/or impairment of β- and γ- secretase's concentration or kinetics as enzymes involving in Aβ production.</p>http://www.behavioralandbrainfunctions.com/content/8/1/4AutismNeurotoxicityAmyloid betaBrain influxCognitive disability |
| spellingShingle | Al- Ayadhi Laila Y Ben Bacha Abir G Kotb Malak El-Ansary Afaf K A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics Behavioral and Brain Functions Autism Neurotoxicity Amyloid beta Brain influx Cognitive disability |
| title | A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics |
| title_full | A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics |
| title_fullStr | A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics |
| title_full_unstemmed | A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics |
| title_short | A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics |
| title_sort | novel study on amyloid β peptide 40 42 and 40 42 ratio in saudi autistics |
| topic | Autism Neurotoxicity Amyloid beta Brain influx Cognitive disability |
| url | http://www.behavioralandbrainfunctions.com/content/8/1/4 |
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