Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
<p>Abstract</p> <p>Background</p> <p>Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.</p> <p>Methods</p> <p>Here, we report a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-07-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/9/1/119 |
| _version_ | 1811266251588108288 |
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| author | Halsey Wendy S Gallagher Kathleen T Parker Joel S Holbrook Joanna D Hughes Ashley M Weigman Victor J Lebowitz Peter F Kumar Rakesh |
| author_facet | Halsey Wendy S Gallagher Kathleen T Parker Joel S Holbrook Joanna D Hughes Ashley M Weigman Victor J Lebowitz Peter F Kumar Rakesh |
| author_sort | Halsey Wendy S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.</p> <p>Methods</p> <p>Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers.</p> <p>Results</p> <p>Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways.</p> <p>Conclusions</p> <p>The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.</p> |
| first_indexed | 2024-04-12T20:38:42Z |
| format | Article |
| id | doaj.art-cef217814c2c4431a8f45e6dea6e9548 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-12T20:38:42Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-cef217814c2c4431a8f45e6dea6e95482022-12-22T03:17:30ZengBMCJournal of Translational Medicine1479-58762011-07-019111910.1186/1479-5876-9-119Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicineHalsey Wendy SGallagher Kathleen TParker Joel SHolbrook Joanna DHughes Ashley MWeigman Victor JLebowitz Peter FKumar Rakesh<p>Abstract</p> <p>Background</p> <p>Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.</p> <p>Methods</p> <p>Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers.</p> <p>Results</p> <p>Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways.</p> <p>Conclusions</p> <p>The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.</p>http://www.translational-medicine.com/content/9/1/119 |
| spellingShingle | Halsey Wendy S Gallagher Kathleen T Parker Joel S Holbrook Joanna D Hughes Ashley M Weigman Victor J Lebowitz Peter F Kumar Rakesh Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine Journal of Translational Medicine |
| title | Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| title_full | Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| title_fullStr | Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| title_full_unstemmed | Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| title_short | Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| title_sort | deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine |
| url | http://www.translational-medicine.com/content/9/1/119 |
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