1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis

1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis

For the first time, the present study unravels a cardiospecific therapeutic approach for Pulmonary Arterial Hypertension (PAH), a disease with a very poor prognosis and high mortality rates due to right ventricle (RV) dysfunction. We first established a new in vitro model of high-pressure-induced hy...

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Bibliographic Details
Main Authors: Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Sofia Viana, Inês Preguiça, Rui Baptista, Cátia Ferreira, Carlos Cavaleiro, Neuza Domingues, Vilma A. Sardão, Paulo J. Oliveira, Flávio Reis, Lígia Salgueiro, Henrique Girão
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Pharmacological Research
Subjects:
1,8-Cineole
Connexin43
Fibrosis
Hypertrophy
Right ventricle
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000962

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