Adaptive redox homeostasis in cutaneous melanoma
Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeostasis have been shown to be involved at each stage o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720309587 |
| _version_ | 1819060801098481664 |
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| author | Liaisan R. Arslanbaeva Massimo M. Santoro |
| author_facet | Liaisan R. Arslanbaeva Massimo M. Santoro |
| author_sort | Liaisan R. Arslanbaeva |
| collection | DOAJ |
| description | Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeostasis have been shown to be involved at each stage of a malignant melanocyte transformation, called melanomagenesis, as well as during drug resistance. Reactive oxygen species (ROS) play an important and diverse role that regulate many aspects of skin cell behaviors ranging from proliferation and stemness, to oxidative damage and cell death. On the other hand, antioxidants are associated with melanoma spread and metastasis. Overall, the contribution of redox homeostasis to melanoma development and progression is controversial and highly complex. The aim of this study is to examine the association between redox homeostasis and the melanomagenic process. To this purpose we are presenting what is currently known about the role of ROS in melanoma initiation and progression. In addition, we are discussing the role of antioxidant mechanisms during the spread of the disease and in cases of melanoma drug resistance. Although challenging, targeting redox homeostasis in melanoma progression remains to be a promising therapeutic approach, especially valid during melanoma drug resistance. |
| first_indexed | 2024-12-21T14:32:45Z |
| format | Article |
| id | doaj.art-cef5ba2365204adba1e092257d712435 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-21T14:32:45Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-cef5ba2365204adba1e092257d7124352022-12-21T19:00:26ZengElsevierRedox Biology2213-23172020-10-0137101753Adaptive redox homeostasis in cutaneous melanomaLiaisan R. Arslanbaeva0Massimo M. Santoro1Department of Biology, University of Padua, 35131, ItalyDepartment of Biology, University of Padua, 35131, Italy; Veneto Institute of Molecular Medicine (VIMM), Via Orus 2, 35129, Padua, Italy; Corresponding author. Department of Biology, University of Padua, 35131, Italy.Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous melanoma accounts for a minority of all types of skin cancer, it causes the greatest number of skin cancer related deaths worldwide. Oxidative stress and redox homeostasis have been shown to be involved at each stage of a malignant melanocyte transformation, called melanomagenesis, as well as during drug resistance. Reactive oxygen species (ROS) play an important and diverse role that regulate many aspects of skin cell behaviors ranging from proliferation and stemness, to oxidative damage and cell death. On the other hand, antioxidants are associated with melanoma spread and metastasis. Overall, the contribution of redox homeostasis to melanoma development and progression is controversial and highly complex. The aim of this study is to examine the association between redox homeostasis and the melanomagenic process. To this purpose we are presenting what is currently known about the role of ROS in melanoma initiation and progression. In addition, we are discussing the role of antioxidant mechanisms during the spread of the disease and in cases of melanoma drug resistance. Although challenging, targeting redox homeostasis in melanoma progression remains to be a promising therapeutic approach, especially valid during melanoma drug resistance.http://www.sciencedirect.com/science/article/pii/S2213231720309587Cutaneous melanomaMelanomagenesisROSRedox homeostasisMetastasisTumor metabolism |
| spellingShingle | Liaisan R. Arslanbaeva Massimo M. Santoro Adaptive redox homeostasis in cutaneous melanoma Redox Biology Cutaneous melanoma Melanomagenesis ROS Redox homeostasis Metastasis Tumor metabolism |
| title | Adaptive redox homeostasis in cutaneous melanoma |
| title_full | Adaptive redox homeostasis in cutaneous melanoma |
| title_fullStr | Adaptive redox homeostasis in cutaneous melanoma |
| title_full_unstemmed | Adaptive redox homeostasis in cutaneous melanoma |
| title_short | Adaptive redox homeostasis in cutaneous melanoma |
| title_sort | adaptive redox homeostasis in cutaneous melanoma |
| topic | Cutaneous melanoma Melanomagenesis ROS Redox homeostasis Metastasis Tumor metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2213231720309587 |
| work_keys_str_mv | AT liaisanrarslanbaeva adaptiveredoxhomeostasisincutaneousmelanoma AT massimomsantoro adaptiveredoxhomeostasisincutaneousmelanoma |