Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study
Background Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking.Methods A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/11/1/e001804.full |
| _version_ | 1797201484704645120 |
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| author | Terence Chi Chun Tam Wang Chun Kwok Chung Ki Tsui Sze Him Isaac Leung Chun Ka Emmanuel Wong James Chung-man Ho |
| author_facet | Terence Chi Chun Tam Wang Chun Kwok Chung Ki Tsui Sze Him Isaac Leung Chun Ka Emmanuel Wong James Chung-man Ho |
| author_sort | Terence Chi Chun Tam |
| collection | DOAJ |
| description | Background Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking.Methods A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed in public hospitals and clinics between 1 January 1993 and 31 December 2017 were included. Patients were allocated to be exacerbator or non-exacerbator group based on hospitalzied bronchiecsis history and CVEs over the next 5 years determined. Propensity score matching was used to balance baseline characteristics.Results 10 714 bronchiectasis patients (mean age 69.6±14.4 years, 38.9% men), including 1230 in exacerbator group and 9484 in non-exacerbator group, were analysed. At 5 years, 113 (9.2%) subjects in the exacerbator group and 87 (7.1%) in the non-exacerbator group developed composite CVEs. After adjustment for age, sex, smoking and risk factors for cardiovascular disease, bronchiectasis exacerbation was associated with increased risks for acute myocardial infarction (AMI), congestive heart failure (CHF) and CVE compared with those in the non-exacerbator group with adjusted HR of 1.602 (95% CI 1.006–2.552, p value=0.047), 1.371 (95% CI 1.016–1.851, p value=0.039) and 1.238 (95% CI 1.001–1.532, p=0.049) in the whole cohort. Findings were similar for the propensity score-matched cohort for AMI and CVE.Conclusion Patients who were hospitalised for exacerbation of bronchiectasis were at significantly increased risk of AMI, CHF and CVE over a 5-year follow-up period. |
| first_indexed | 2024-04-24T07:48:17Z |
| format | Article |
| id | doaj.art-cef9dd6a0771484f8f63de542d5b7647 |
| institution | Directory Open Access Journal |
| issn | 2052-4439 |
| language | English |
| last_indexed | 2024-04-24T07:48:17Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj.art-cef9dd6a0771484f8f63de542d5b76472024-04-18T18:05:11ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392024-04-0111110.1136/bmjresp-2023-001804Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide studyTerence Chi Chun Tam0Wang Chun Kwok1Chung Ki Tsui2Sze Him Isaac Leung3Chun Ka Emmanuel Wong4James Chung-man Ho5residentDepartment of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Statistics, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongBackground Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking.Methods A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed in public hospitals and clinics between 1 January 1993 and 31 December 2017 were included. Patients were allocated to be exacerbator or non-exacerbator group based on hospitalzied bronchiecsis history and CVEs over the next 5 years determined. Propensity score matching was used to balance baseline characteristics.Results 10 714 bronchiectasis patients (mean age 69.6±14.4 years, 38.9% men), including 1230 in exacerbator group and 9484 in non-exacerbator group, were analysed. At 5 years, 113 (9.2%) subjects in the exacerbator group and 87 (7.1%) in the non-exacerbator group developed composite CVEs. After adjustment for age, sex, smoking and risk factors for cardiovascular disease, bronchiectasis exacerbation was associated with increased risks for acute myocardial infarction (AMI), congestive heart failure (CHF) and CVE compared with those in the non-exacerbator group with adjusted HR of 1.602 (95% CI 1.006–2.552, p value=0.047), 1.371 (95% CI 1.016–1.851, p value=0.039) and 1.238 (95% CI 1.001–1.532, p=0.049) in the whole cohort. Findings were similar for the propensity score-matched cohort for AMI and CVE.Conclusion Patients who were hospitalised for exacerbation of bronchiectasis were at significantly increased risk of AMI, CHF and CVE over a 5-year follow-up period.https://bmjopenrespres.bmj.com/content/11/1/e001804.full |
| spellingShingle | Terence Chi Chun Tam Wang Chun Kwok Chung Ki Tsui Sze Him Isaac Leung Chun Ka Emmanuel Wong James Chung-man Ho Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study BMJ Open Respiratory Research |
| title | Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study |
| title_full | Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study |
| title_fullStr | Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study |
| title_full_unstemmed | Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study |
| title_short | Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study |
| title_sort | cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis a territory wide study |
| url | https://bmjopenrespres.bmj.com/content/11/1/e001804.full |
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