Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs
Brain metastasis is the most prevalent neurologic problem of systemic cancer and it can increase the mortality rate in patients with cancer. It occurs more in patients with lung cancer, breast cancer, and melanoma. There are several molecular mechanisms in cancer cell progression, invasion, and loca...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2024-04-01
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| Series: | Exploration of Neuroscience |
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| Online Access: | https://www.explorationpub.com/Journals/en/Article/100640 |
| _version_ | 1797205869920780288 |
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| author | Zohreh Khosravi Dehaghi |
| author_facet | Zohreh Khosravi Dehaghi |
| author_sort | Zohreh Khosravi Dehaghi |
| collection | DOAJ |
| description | Brain metastasis is the most prevalent neurologic problem of systemic cancer and it can increase the mortality rate in patients with cancer. It occurs more in patients with lung cancer, breast cancer, and melanoma. There are several molecular mechanisms in cancer cell progression, invasion, and location in new places during brain metastasis. Significant interactions between cancer cells, the brain microenvironment, and the blood-brain barrier (BBB) play a major role in brain metastasis. This study will focus on molecular mechanisms that contribute to cancer metastasis into the brain and finding new treatments with molecular research. Treatment strategies in patients with brain metastasis include surgical resection, radiotherapy, and chemotherapy; however, the penetration of chemotherapy drugs beyond the BBB is limited. Studying molecular, cellular, and physical mechanisms in brain metastasis helps to improve new strategies in drug delivery across the BBB. There are significant impacts of ion channels in brain metastasis and cancer treatment failure. Targeting molecular mechanisms and ion channels in brain metastasis led to increasing the better response in these patients. In this way, nano-drugs have caused a revolution in effective targeting and drug delivery in cancer treatment. This review describes the advances to facilitate the penetration of drugs in the BBB by using nano-drugs especially those that are targeting ion channels. |
| first_indexed | 2024-04-24T08:57:59Z |
| format | Article |
| id | doaj.art-cefb7e1f95e2442090e1a5737ab4060b |
| institution | Directory Open Access Journal |
| issn | 2834-5347 |
| language | English |
| last_indexed | 2024-04-24T08:57:59Z |
| publishDate | 2024-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroscience |
| spelling | doaj.art-cefb7e1f95e2442090e1a5737ab4060b2024-04-16T05:19:30ZengOpen Exploration Publishing Inc.Exploration of Neuroscience2834-53472024-04-013213014310.37349/en.2024.00040Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugsZohreh Khosravi Dehaghi0https://orcid.org/0009-0008-4686-2331Department of Cell and Molecular biology & Microbiology, University of Isfahan, Isfahan 8174673441, IranBrain metastasis is the most prevalent neurologic problem of systemic cancer and it can increase the mortality rate in patients with cancer. It occurs more in patients with lung cancer, breast cancer, and melanoma. There are several molecular mechanisms in cancer cell progression, invasion, and location in new places during brain metastasis. Significant interactions between cancer cells, the brain microenvironment, and the blood-brain barrier (BBB) play a major role in brain metastasis. This study will focus on molecular mechanisms that contribute to cancer metastasis into the brain and finding new treatments with molecular research. Treatment strategies in patients with brain metastasis include surgical resection, radiotherapy, and chemotherapy; however, the penetration of chemotherapy drugs beyond the BBB is limited. Studying molecular, cellular, and physical mechanisms in brain metastasis helps to improve new strategies in drug delivery across the BBB. There are significant impacts of ion channels in brain metastasis and cancer treatment failure. Targeting molecular mechanisms and ion channels in brain metastasis led to increasing the better response in these patients. In this way, nano-drugs have caused a revolution in effective targeting and drug delivery in cancer treatment. This review describes the advances to facilitate the penetration of drugs in the BBB by using nano-drugs especially those that are targeting ion channels.https://www.explorationpub.com/Journals/en/Article/100640brain metastasesgenetic alterationsblood-brain barrierepithelial-mesenchymal transitionion channelnano-drug |
| spellingShingle | Zohreh Khosravi Dehaghi Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs Exploration of Neuroscience brain metastases genetic alterations blood-brain barrier epithelial-mesenchymal transition ion channel nano-drug |
| title | Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs |
| title_full | Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs |
| title_fullStr | Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs |
| title_full_unstemmed | Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs |
| title_short | Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs |
| title_sort | brain metastasis from the perspective of molecular mechanisms and treatment presenting a new approach for targeting ion channels by nano drugs |
| topic | brain metastases genetic alterations blood-brain barrier epithelial-mesenchymal transition ion channel nano-drug |
| url | https://www.explorationpub.com/Journals/en/Article/100640 |
| work_keys_str_mv | AT zohrehkhosravidehaghi brainmetastasisfromtheperspectiveofmolecularmechanismsandtreatmentpresentinganewapproachfortargetingionchannelsbynanodrugs |