Importance of Germline and Somatic Alterations in Human <i>MRE11</i>, <i>RAD50</i>, and <i>NBN</i> Genes Coding for MRN Complex

Importance of Germline and Somatic Alterations in Human <i>MRE11</i>, <i>RAD50</i>, and <i>NBN</i> Genes Coding for MRN Complex

The <i>MRE11</i>, <i>RAD50</i>, and <i>NBN</i> genes encode for the nuclear MRN protein complex, which senses the DNA double strand breaks and initiates the DNA repair. The MRN complex also participates in the activation of ATM kinase, which coordinates DNA repair...

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Bibliographic Details
Main Authors: Barbora Otahalova, Zuzana Volkova, Jana Soukupova, Petra Kleiblova, Marketa Janatova, Michal Vocka, Libor Macurek, Zdenek Kleibl
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
NBN
MRE11
RAD50
NBS
ATLD
NBSLD
Online Access:https://www.mdpi.com/1422-0067/24/6/5612

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