Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation
The fruits of Barringtonia racemosa are traditionally used in Indian medicine for the treatment of pain and inflammatory conditions. In this study, a fraction of ethyl acetate extract of fruits of B. racemosa (BREAF) was investigated for anti-inflammatory activity in experimental models of acute and...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016000249 |
| _version_ | 1811217836290342912 |
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| author | Kalpesh R. Patil Chandragouda R. Patil |
| author_facet | Kalpesh R. Patil Chandragouda R. Patil |
| author_sort | Kalpesh R. Patil |
| collection | DOAJ |
| description | The fruits of Barringtonia racemosa are traditionally used in Indian medicine for the treatment of pain and inflammatory conditions. In this study, a fraction of ethyl acetate extract of fruits of B. racemosa (BREAF) was investigated for anti-inflammatory activity in experimental models of acute and chronic inflammation. Activity against acute inflammation was evaluated in inflammogens induced rat paw edema models. Whereas, effect in chronic inflammation was evaluated in cotton pellet granuloma and oxazolone induced delayed type hypersensitivity (DTH) model in mice. The BREAF exhibited dose dependent anti-inflammatory activity in both acute and chronic models at oral doses of 5, 10 and 20 mg/kg. BREAF inhibited both phases of carrageenan induced rat paw inflammation. The reduction in paw inflammation by BREAF was also evident in histamine and serotonin induced inflammation in rats. Effect of BREAF on DTH indicates inhibition of immune mediated inflammation. The reduction in cotton pellet granuloma by BREAF treatment shows inhibition of proliferative changes associated with chronic inflammation. Analysis of BREAF after chromatographic separations showed presence of bartogenic acid as a major constituent. Hence, it is proposed that anti-inflammatory effects of BREAF can be partially attributed to its bartogenic acid content. The minute doses at which this fraction shows anti-inflammatory effects emphasizes the need for further investigations on its efficacy in the immuno-inflammatory conditions. |
| first_indexed | 2024-04-12T07:01:21Z |
| format | Article |
| id | doaj.art-cefdf3bc889d448fa2ffa40f02628f6c |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-12T07:01:21Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-cefdf3bc889d448fa2ffa40f02628f6c2022-12-22T03:43:00ZengElsevierJournal of Traditional and Complementary Medicine2225-41102017-01-0171869310.1016/j.jtcme.2016.02.001Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammationKalpesh R. Patil0Chandragouda R. Patil1Department of Pharmacology, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Dist-Dhule, Maharashtra, IndiaDepartment of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Dist-Dhule, Maharashtra, IndiaThe fruits of Barringtonia racemosa are traditionally used in Indian medicine for the treatment of pain and inflammatory conditions. In this study, a fraction of ethyl acetate extract of fruits of B. racemosa (BREAF) was investigated for anti-inflammatory activity in experimental models of acute and chronic inflammation. Activity against acute inflammation was evaluated in inflammogens induced rat paw edema models. Whereas, effect in chronic inflammation was evaluated in cotton pellet granuloma and oxazolone induced delayed type hypersensitivity (DTH) model in mice. The BREAF exhibited dose dependent anti-inflammatory activity in both acute and chronic models at oral doses of 5, 10 and 20 mg/kg. BREAF inhibited both phases of carrageenan induced rat paw inflammation. The reduction in paw inflammation by BREAF was also evident in histamine and serotonin induced inflammation in rats. Effect of BREAF on DTH indicates inhibition of immune mediated inflammation. The reduction in cotton pellet granuloma by BREAF treatment shows inhibition of proliferative changes associated with chronic inflammation. Analysis of BREAF after chromatographic separations showed presence of bartogenic acid as a major constituent. Hence, it is proposed that anti-inflammatory effects of BREAF can be partially attributed to its bartogenic acid content. The minute doses at which this fraction shows anti-inflammatory effects emphasizes the need for further investigations on its efficacy in the immuno-inflammatory conditions.http://www.sciencedirect.com/science/article/pii/S2225411016000249Barringtonia racemosalecythidaceaebartogenic acidanti-inflammatorydelayed type hypersensitivity |
| spellingShingle | Kalpesh R. Patil Chandragouda R. Patil Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation Journal of Traditional and Complementary Medicine Barringtonia racemosa lecythidaceae bartogenic acid anti-inflammatory delayed type hypersensitivity |
| title | Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation |
| title_full | Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation |
| title_fullStr | Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation |
| title_full_unstemmed | Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation |
| title_short | Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation |
| title_sort | anti inflammatory activity of bartogenic acid containing fraction of fruits of barringtonia racemosa roxb in acute and chronic animal models of inflammation |
| topic | Barringtonia racemosa lecythidaceae bartogenic acid anti-inflammatory delayed type hypersensitivity |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016000249 |
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