Radiation-Induced Changes in Tumor Vessels and Microenvironment Contribute to Therapeutic Resistance in Glioblastoma

Radiation-Induced Changes in Tumor Vessels and Microenvironment Contribute to Therapeutic Resistance in Glioblastoma

Glioblastoma (GBM) is a largely fatal and highly angiogenic malignancy with a median patient survival of just over 1 year with radiotherapy (RT). The effects of RT on GBM remain unclear, although increasing evidence suggests that RT-induced alterations in the brain microenvironment affect the recurr...

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Bibliographic Details
Main Authors: Yun-Soo Seo, In Ok Ko, Hyejin Park, Ye Ji Jeong, Ji-Ae Park, Kwang Seok Kim, Myung-Jin Park, Hae-June Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
glioma stem cell
radiotherapy
tumor microenvironment
tumor vessel
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01259/full

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