The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study
Yue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-05-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-relationship-between-blood-brain-barrier-permeability-and-enlarged-peer-reviewed-article-CIA |
| _version_ | 1818399252012859392 |
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| author | Li Y Li M Yang L Qin W Yang S Yuan J Jiang T Hu W |
| author_facet | Li Y Li M Yang L Qin W Yang S Yuan J Jiang T Hu W |
| author_sort | Li Y |
| collection | DOAJ |
| description | Yue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaPurpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear. Compromised blood–brain barrier (BBB) integrity may play a role since previous studies have shown that BBB breakdown is a critical contributor to the pathogenesis of other cSVD markers. This study aimed to investigate the association of EPVS in the centrum semiovale (CSO) and basal ganglia (BG) with BBB permeability.Patients and methods: Consecutive participants free of symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study. CSO- and BG-EPVS on T2-weighted (T2-W) magnetic resonance imaging (MRI) were rated using a five-point validated scale. Dynamic contrast-enhanced (DCE)-MRI and Patlak pharmacokinetic model were applied to quantify BBB permeability in the CSO and BG.Results: A total of 109 participants aged 49–90 years (mean age of 69.85 years) were enrolled. The proportions of participants presenting high-grade (>10) EPVS in the CSO and BG were 50.5% and 44.0%, respectively. After adjustments for potential confounders by logistic regression, leakage rate and fractional blood plasma volume were correlated with the severity of BG-EPVS (OR: 5.33; 95%CI: 1.95–14.60 and OR: 0.93; 95%CI: 0.87–0.99).Conclusion: Our study demonstrates that BG-EPVS are associated with compromised BBB integrity, supporting the hypothesis that the BBB dysfunction may be involved in the pathogenesis of BG-EPVS. EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRI |
| first_indexed | 2024-12-14T07:17:43Z |
| format | Article |
| id | doaj.art-cf00e3256b5940feb209a61d7c73fccb |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-14T07:17:43Z |
| publishDate | 2019-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-cf00e3256b5940feb209a61d7c73fccb2022-12-21T23:11:41ZengDove Medical PressClinical Interventions in Aging1178-19982019-05-01Volume 1487187845746The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional studyLi YLi MYang LQin WYang SYuan JJiang THu WYue Li,1 Man Li,2 Lei Yang,1 Wei Qin,1 Shuna Yang,1 Junliang Yuan,1 Tao Jiang,2 Wenli Hu11Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of ChinaPurpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear. Compromised blood–brain barrier (BBB) integrity may play a role since previous studies have shown that BBB breakdown is a critical contributor to the pathogenesis of other cSVD markers. This study aimed to investigate the association of EPVS in the centrum semiovale (CSO) and basal ganglia (BG) with BBB permeability.Patients and methods: Consecutive participants free of symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study. CSO- and BG-EPVS on T2-weighted (T2-W) magnetic resonance imaging (MRI) were rated using a five-point validated scale. Dynamic contrast-enhanced (DCE)-MRI and Patlak pharmacokinetic model were applied to quantify BBB permeability in the CSO and BG.Results: A total of 109 participants aged 49–90 years (mean age of 69.85 years) were enrolled. The proportions of participants presenting high-grade (>10) EPVS in the CSO and BG were 50.5% and 44.0%, respectively. After adjustments for potential confounders by logistic regression, leakage rate and fractional blood plasma volume were correlated with the severity of BG-EPVS (OR: 5.33; 95%CI: 1.95–14.60 and OR: 0.93; 95%CI: 0.87–0.99).Conclusion: Our study demonstrates that BG-EPVS are associated with compromised BBB integrity, supporting the hypothesis that the BBB dysfunction may be involved in the pathogenesis of BG-EPVS. EPVS in the CSO and BG may have distinct pathophysiology.Keywords: enlarged perivascular spaces, cerebral small vessel disease, blood–brain barrier, dynamic contrast-enhanced, DCE, magnetic resonance imaging, MRIhttps://www.dovepress.com/the-relationship-between-blood-brain-barrier-permeability-and-enlarged-peer-reviewed-article-CIAEnlarged perivascular spacesCerebral small vessel diseaseBlood-brain barrierDynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI). |
| spellingShingle | Li Y Li M Yang L Qin W Yang S Yuan J Jiang T Hu W The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study Clinical Interventions in Aging Enlarged perivascular spaces Cerebral small vessel disease Blood-brain barrier Dynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI). |
| title | The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study |
| title_full | The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study |
| title_fullStr | The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study |
| title_full_unstemmed | The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study |
| title_short | The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study |
| title_sort | relationship between blood ndash brain barrier permeability and enlarged perivascular spaces a cross sectional study |
| topic | Enlarged perivascular spaces Cerebral small vessel disease Blood-brain barrier Dynamic contrast-enhanced (DCE)-Magnetic Resonance Imaging (MRI). |
| url | https://www.dovepress.com/the-relationship-between-blood-brain-barrier-permeability-and-enlarged-peer-reviewed-article-CIA |
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