Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket

Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket

The transcription repressor of D-galactonate metabolism, DgoR, from Escherichia coli belongs to the FadR family of the GntR superfamily. In the presence of D-galactonate, DgoR binds to two inverted repeats overlapping the dgo cis-acting promoter repressing the expression of genes involved in D-galac...

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Bibliographic Details
Main Authors: Zhaozhu Lin, Yi Sun, Yu Liu, Shujuan Tong, Zhuo Shang, Yuanheng Cai, Wei Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
DgoR
metal binding site
D-galactonate
FadR family
Escherichia coli
transcription repressor
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.590330/full

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