Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Thoug...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2761 |
| _version_ | 1797515035405189120 |
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| author | Parveen Bazard Jennifer Pineros Robert D. Frisina Mark A. Bauer Alejandro A. Acosta Lauren R. Paganella Dominika Borakiewicz Mark Thivierge Freyda L. Mannering Xiaoxia Zhu Bo Ding |
| author_facet | Parveen Bazard Jennifer Pineros Robert D. Frisina Mark A. Bauer Alejandro A. Acosta Lauren R. Paganella Dominika Borakiewicz Mark Thivierge Freyda L. Mannering Xiaoxia Zhu Bo Ding |
| author_sort | Parveen Bazard |
| collection | DOAJ |
| description | The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age. |
| first_indexed | 2024-03-10T06:39:54Z |
| format | Article |
| id | doaj.art-cf01738b5d2342cfab861cdf5fb688e1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:54Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-cf01738b5d2342cfab861cdf5fb688e12023-11-22T17:48:47ZengMDPI AGCells2073-44092021-10-011010276110.3390/cells10102761Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial FunctionsParveen Bazard0Jennifer Pineros1Robert D. Frisina2Mark A. Bauer3Alejandro A. Acosta4Lauren R. Paganella5Dominika Borakiewicz6Mark Thivierge7Freyda L. Mannering8Xiaoxia Zhu9Bo Ding10Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USAGlobal Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USADepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USAThe slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.https://www.mdpi.com/2073-4409/10/10/2761aginginflammagingauditory systemage-related hearing losscochlea |
| spellingShingle | Parveen Bazard Jennifer Pineros Robert D. Frisina Mark A. Bauer Alejandro A. Acosta Lauren R. Paganella Dominika Borakiewicz Mark Thivierge Freyda L. Mannering Xiaoxia Zhu Bo Ding Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions Cells aging inflammaging auditory system age-related hearing loss cochlea |
| title | Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions |
| title_full | Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions |
| title_fullStr | Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions |
| title_full_unstemmed | Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions |
| title_short | Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions |
| title_sort | cochlear inflammaging in relation to ion channels and mitochondrial functions |
| topic | aging inflammaging auditory system age-related hearing loss cochlea |
| url | https://www.mdpi.com/2073-4409/10/10/2761 |
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