Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules
Background: In Taiwan, the age group with the greatest incidence of invasive pneumococcal disease is 2–5 years of age, which is different from other countries. This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with v...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-04-01
|
| Series: | Journal of Microbiology, Immunology and Infection |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118217302050 |
| _version_ | 1811295009025032192 |
|---|---|
| author | Hong-Yi Lee Yu-Chia Hsieh Ching-Chuan Liu Yi-Chuan Huang Kuang-Yi Chang Hsin Chi Luan-Yin Chang Yhu-Chering Huang Li-Min Huang |
| author_facet | Hong-Yi Lee Yu-Chia Hsieh Ching-Chuan Liu Yi-Chuan Huang Kuang-Yi Chang Hsin Chi Luan-Yin Chang Yhu-Chering Huang Li-Min Huang |
| author_sort | Hong-Yi Lee |
| collection | DOAJ |
| description | Background: In Taiwan, the age group with the greatest incidence of invasive pneumococcal disease is 2–5 years of age, which is different from other countries. This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination. Methods: A case–control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers. The study enrolled children <15 years of age who were admitted to one of the five medical centers for CAP. Blood samples and acute-phase serum specimens were collected and Streptococcus pneumoniae was identified by using a real-time polymerase-chain-reaction (RT-PCR) assay targeting the lytA gene. Results: A total of 25 children diagnosed with vaccine-type IPP and 124 controls were enrolled. Vaccine-type IPP occurred in 6 (28.6%), 14 (24.1%), and 5 (7.1%) children receiving vaccines on a not-age-appropriate schedule (n = 21), primary infant schedule (n = 58), and toddler catch-up schedule (n = 70) (P = 0.008), respectively. Of 25 children, the mean age at disease onset was 36 ± 11 months; serotype 19A was responsible for 84% (21/25). Conclusion: After adjustment for confounding factors, the risk of vaccine-type IPP was significantly higher among children receiving vaccines on a not-age-appropriate schedule, or on a primary infant schedule, compared with children receiving vaccines on a toddler catch-up schedule. Duration of vaccine immunity should be investigated to direct strategies for maintaining individual and population immunity against pneumococcal disease. Keywords: 13-Valent conjugate pneumococcal vaccine, Invasive pneumococcal pneumonia, Vaccine schedule |
| first_indexed | 2024-04-13T05:26:59Z |
| format | Article |
| id | doaj.art-cf02a738dab84928b3eae5ec65b8829f |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-13T05:26:59Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-cf02a738dab84928b3eae5ec65b8829f2022-12-22T03:00:34ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822018-04-01512199206Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedulesHong-Yi Lee0Yu-Chia Hsieh1Ching-Chuan Liu2Yi-Chuan Huang3Kuang-Yi Chang4Hsin Chi5Luan-Yin Chang6Yhu-Chering Huang7Li-Min Huang8Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kwei-Shan Hsiang, Taoyuan County, Taiwan. Fax: +886-3-3288957.Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Biostatistics, Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan; Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, TaiwanDepartment of Pediatrics, Mackay Memorial Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Chang Gung University, College of Medicine, Taoyuan, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanBackground: In Taiwan, the age group with the greatest incidence of invasive pneumococcal disease is 2–5 years of age, which is different from other countries. This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination. Methods: A case–control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers. The study enrolled children <15 years of age who were admitted to one of the five medical centers for CAP. Blood samples and acute-phase serum specimens were collected and Streptococcus pneumoniae was identified by using a real-time polymerase-chain-reaction (RT-PCR) assay targeting the lytA gene. Results: A total of 25 children diagnosed with vaccine-type IPP and 124 controls were enrolled. Vaccine-type IPP occurred in 6 (28.6%), 14 (24.1%), and 5 (7.1%) children receiving vaccines on a not-age-appropriate schedule (n = 21), primary infant schedule (n = 58), and toddler catch-up schedule (n = 70) (P = 0.008), respectively. Of 25 children, the mean age at disease onset was 36 ± 11 months; serotype 19A was responsible for 84% (21/25). Conclusion: After adjustment for confounding factors, the risk of vaccine-type IPP was significantly higher among children receiving vaccines on a not-age-appropriate schedule, or on a primary infant schedule, compared with children receiving vaccines on a toddler catch-up schedule. Duration of vaccine immunity should be investigated to direct strategies for maintaining individual and population immunity against pneumococcal disease. Keywords: 13-Valent conjugate pneumococcal vaccine, Invasive pneumococcal pneumonia, Vaccine schedulehttp://www.sciencedirect.com/science/article/pii/S1684118217302050 |
| spellingShingle | Hong-Yi Lee Yu-Chia Hsieh Ching-Chuan Liu Yi-Chuan Huang Kuang-Yi Chang Hsin Chi Luan-Yin Chang Yhu-Chering Huang Li-Min Huang Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules Journal of Microbiology, Immunology and Infection |
| title | Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules |
| title_full | Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules |
| title_fullStr | Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules |
| title_full_unstemmed | Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules |
| title_short | Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules |
| title_sort | invasive pneumococcal pneumonia caused by 13 valent pneumococcal conjugate vaccine types in children with different schedules |
| url | http://www.sciencedirect.com/science/article/pii/S1684118217302050 |
| work_keys_str_mv | AT hongyilee invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT yuchiahsieh invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT chingchuanliu invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT yichuanhuang invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT kuangyichang invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT hsinchi invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT luanyinchang invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT yhucheringhuang invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules AT liminhuang invasivepneumococcalpneumoniacausedby13valentpneumococcalconjugatevaccinetypesinchildrenwithdifferentschedules |