Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Inhibition of protein–DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique oligoamide-based foldamers that adopt single helical conformations and mimic the negatively charged phosphate moieties of B-DNA. These mimics alter t...

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Bibliographic Details
Main Authors: Valentina Corvaglia, Imène Ait Mohamed Amar, Véronique Garambois, Stéphanie Letast, Aurélie Garcin, Céline Gongora, Maguy Del Rio, Caroline Denevault-Sabourin, Nicolas Joubert, Ivan Huc, Philippe Pourquier
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
DNA mimics
foldamer
antibody-drug conjugate
trastuzumab
HER2
Online Access:https://www.mdpi.com/1424-8247/14/7/624

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