Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris
Abstract Invasive Candida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in several Candida species that cause Candidemia, including C. glabrata and C. auris,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | MicrobiologyOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mbo3.1218 |
| _version_ | 1818910334931435520 |
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| author | Asad Hamad Yiyuan Chen Mohsin A. Khan Shirin Jamshidi Naima Saeed Melanie Clifford Charlotte Hind J. Mark Sutton Khondaker Miraz Rahman |
| author_facet | Asad Hamad Yiyuan Chen Mohsin A. Khan Shirin Jamshidi Naima Saeed Melanie Clifford Charlotte Hind J. Mark Sutton Khondaker Miraz Rahman |
| author_sort | Asad Hamad |
| collection | DOAJ |
| description | Abstract Invasive Candida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in several Candida species that cause Candidemia, including C. glabrata and C. auris, with limited numbers of antifungal agents available to treat patients with invasive Candida infections. Therefore, there is an urgent need to discover new antifungal agents that work against multidrug‐resistant Candida species, particularly C. auris, which has been identified as an emerging global pathogen. In this article, we report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against all Candida species tested, with an MIC range of 4–32 µg/ml. Compound 2b showed activity against C. glabrata and a panel of fluconazole‐resistant C. auris strains, with MICs of 4–16 µg/ml. The drug‐like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed toward pre‐clinical evaluation. |
| first_indexed | 2024-12-19T22:41:10Z |
| format | Article |
| id | doaj.art-cf0580f3457849ba8a387560e55cf5aa |
| institution | Directory Open Access Journal |
| issn | 2045-8827 |
| language | English |
| last_indexed | 2024-12-19T22:41:10Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | MicrobiologyOpen |
| spelling | doaj.art-cf0580f3457849ba8a387560e55cf5aa2022-12-21T20:03:04ZengWileyMicrobiologyOpen2045-88272021-08-01104n/an/a10.1002/mbo3.1218Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida aurisAsad Hamad0Yiyuan Chen1Mohsin A. Khan2Shirin Jamshidi3Naima Saeed4Melanie Clifford5Charlotte Hind6J. Mark Sutton7Khondaker Miraz Rahman8Department of Pharmacy The Islamia University of Bahawalpur Bahawalpur PakistanInstitute of Pharmaceutical Science King's College London London UKDepartment of Pharmacy The Islamia University of Bahawalpur Bahawalpur PakistanInstitute of Pharmaceutical Science King's College London London UKInstitute of Pharmaceutical Science King's College London London UKPublic Health England National Infections Service Salisbury UKPublic Health England National Infections Service Salisbury UKPublic Health England National Infections Service Salisbury UKInstitute of Pharmaceutical Science King's College London London UKAbstract Invasive Candida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in several Candida species that cause Candidemia, including C. glabrata and C. auris, with limited numbers of antifungal agents available to treat patients with invasive Candida infections. Therefore, there is an urgent need to discover new antifungal agents that work against multidrug‐resistant Candida species, particularly C. auris, which has been identified as an emerging global pathogen. In this article, we report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against all Candida species tested, with an MIC range of 4–32 µg/ml. Compound 2b showed activity against C. glabrata and a panel of fluconazole‐resistant C. auris strains, with MICs of 4–16 µg/ml. The drug‐like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed toward pre‐clinical evaluation.https://doi.org/10.1002/mbo3.1218antifungal resistanceCandida auriscandidemiaSchiff basessulphonamides |
| spellingShingle | Asad Hamad Yiyuan Chen Mohsin A. Khan Shirin Jamshidi Naima Saeed Melanie Clifford Charlotte Hind J. Mark Sutton Khondaker Miraz Rahman Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris MicrobiologyOpen antifungal resistance Candida auris candidemia Schiff bases sulphonamides |
| title | Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris |
| title_full | Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris |
| title_fullStr | Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris |
| title_full_unstemmed | Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris |
| title_short | Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris |
| title_sort | schiff bases of sulphonamides as a new class of antifungal agent against multidrug resistant candida auris |
| topic | antifungal resistance Candida auris candidemia Schiff bases sulphonamides |
| url | https://doi.org/10.1002/mbo3.1218 |
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