Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases
Cardiovascular disease constitutes a noteworthy public health challenge characterized by a pronounced incidence, frequency, and mortality rate, particularly impacting specific demographic groups, and imposing a substantial burden on the healthcare infrastructure. Certain risk factors, such as age, g...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/3/381 |
| _version_ | 1797239686470565888 |
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| author | Jennifer McDonald Sidhesh Mohak Zsolt Fabian |
| author_facet | Jennifer McDonald Sidhesh Mohak Zsolt Fabian |
| author_sort | Jennifer McDonald |
| collection | DOAJ |
| description | Cardiovascular disease constitutes a noteworthy public health challenge characterized by a pronounced incidence, frequency, and mortality rate, particularly impacting specific demographic groups, and imposing a substantial burden on the healthcare infrastructure. Certain risk factors, such as age, gender, and smoking, contribute to the prevalence of fatal cardiovascular disease, highlighting the need for targeted interventions. Current challenges in clinical practice involve medication complexities, the lack of a systematic decision-making approach, and prevalent drug therapy problems. Stem cell-derived extracellular vesicles stand as versatile entities with a unique molecular fingerprint, holding significant therapeutic potential across a spectrum of applications, particularly in the realm of cardio-protection. Their lipid, protein, and nucleic acid compositions, coupled with their multifaceted functions, underscore their role as promising mediators in regenerative medicine and pave the way for further exploration of their intricate contributions to cellular physiology and pathology. Here, we overview our current understanding of the possible role of stem cell-derived extracellular vesicles in the clinical management of human cardiovascular pathologies. |
| first_indexed | 2024-04-24T17:55:29Z |
| format | Article |
| id | doaj.art-cf09f94551ff42d8a8eb11814169a3ab |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-24T17:55:29Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cf09f94551ff42d8a8eb11814169a3ab2024-03-27T13:59:46ZengMDPI AGPharmaceutics1999-49232024-03-0116338110.3390/pharmaceutics16030381Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular DiseasesJennifer McDonald0Sidhesh Mohak1Zsolt Fabian2School of Medicine and Dentistry, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Fylde Road, Preston PR1 2HE, UKDepartment of Internal Medicine, South Texas Health System, McAllen, TX 78503, USASchool of Medicine and Dentistry, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Fylde Road, Preston PR1 2HE, UKCardiovascular disease constitutes a noteworthy public health challenge characterized by a pronounced incidence, frequency, and mortality rate, particularly impacting specific demographic groups, and imposing a substantial burden on the healthcare infrastructure. Certain risk factors, such as age, gender, and smoking, contribute to the prevalence of fatal cardiovascular disease, highlighting the need for targeted interventions. Current challenges in clinical practice involve medication complexities, the lack of a systematic decision-making approach, and prevalent drug therapy problems. Stem cell-derived extracellular vesicles stand as versatile entities with a unique molecular fingerprint, holding significant therapeutic potential across a spectrum of applications, particularly in the realm of cardio-protection. Their lipid, protein, and nucleic acid compositions, coupled with their multifaceted functions, underscore their role as promising mediators in regenerative medicine and pave the way for further exploration of their intricate contributions to cellular physiology and pathology. Here, we overview our current understanding of the possible role of stem cell-derived extracellular vesicles in the clinical management of human cardiovascular pathologies.https://www.mdpi.com/1999-4923/16/3/381stem cell-derived extracellular vesiclesexosomesmicrovesiclescardiovascular diseasesregenerative medicine |
| spellingShingle | Jennifer McDonald Sidhesh Mohak Zsolt Fabian Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases Pharmaceutics stem cell-derived extracellular vesicles exosomes microvesicles cardiovascular diseases regenerative medicine |
| title | Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases |
| title_full | Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases |
| title_fullStr | Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases |
| title_full_unstemmed | Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases |
| title_short | Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases |
| title_sort | stem cell derived extracellular vesicles in the treatment of cardiovascular diseases |
| topic | stem cell-derived extracellular vesicles exosomes microvesicles cardiovascular diseases regenerative medicine |
| url | https://www.mdpi.com/1999-4923/16/3/381 |
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