The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study
Abstract Background Smoking, biomass, and occupational exposure are the main environmental risk factors for asthma. The purpose of this study was to analyze the clinical characteristics of exposure to these risk factors in patients with asthma. Methods This cross‐sectional study enrolled patients wi...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.923 |
| _version_ | 1797782647625220096 |
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| author | Laiheng Luo |
| author_facet | Laiheng Luo |
| author_sort | Laiheng Luo |
| collection | DOAJ |
| description | Abstract Background Smoking, biomass, and occupational exposure are the main environmental risk factors for asthma. The purpose of this study was to analyze the clinical characteristics of exposure to these risk factors in patients with asthma. Methods This cross‐sectional study enrolled patients with asthma from an outpatient department according to the Global Initiative for Asthma. Demographics, forced expiratory volume in 1 s (FEV1), FEV1%pred, FEV1/forced vital capacity (FVC), laboratory tests, asthma control test (ACT), asthma control questionnaire (ACQ) scores, and the inhaled corticosteroid (ICS) dose were recorded. A generalized linear mixed model was used to adjust for potential confounders. Results A total of 492 patients with asthma were included in this study. Of these patients, 13.0% were current smokers, 9.6% were former smokers, and 77.4% were never smokers. Compared with never smokers, the current and former smokers had a longer duration of asthma; lower ACT scores, FEV1, FEV1%pred, and FEV1/FVC; and higher ACQ scores, IgE, FeNO, blood eosinophils, and ICS dose (p < .05). In addition, the patients exposed to biomass alone were older; had higher exacerbation in the past year; a longer duration of asthma; and lower FEV1, FEV1%pred, FEV1/FVC, IgE, and FeNO compared with smoking or occupational exposure alone. Compared with smoking exposure alone, patients with occupational exposure alone had a longer duration of asthma and lower FEV1, FEV1%pred, FVC, IgE, FeNO, and ICS dose (p < .05). Conclusions There are significant differences in the clinical characteristics of patients with asthma depending on the smoking status. In addition, significant differences also observed among smoking, biomass, and occupational exposure. |
| first_indexed | 2024-03-13T00:13:55Z |
| format | Article |
| id | doaj.art-cf0a0df180084665b9e756aa4c9bfed6 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-13T00:13:55Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-cf0a0df180084665b9e756aa4c9bfed62023-07-12T07:20:49ZengWileyImmunity, Inflammation and Disease2050-45272023-06-01116n/an/a10.1002/iid3.923The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional studyLaiheng Luo0Department of Respiratory Medicine Jiangxi Province Hospital of Integrated Chinese and Western Medicine Nanchang Jiangxi ChinaAbstract Background Smoking, biomass, and occupational exposure are the main environmental risk factors for asthma. The purpose of this study was to analyze the clinical characteristics of exposure to these risk factors in patients with asthma. Methods This cross‐sectional study enrolled patients with asthma from an outpatient department according to the Global Initiative for Asthma. Demographics, forced expiratory volume in 1 s (FEV1), FEV1%pred, FEV1/forced vital capacity (FVC), laboratory tests, asthma control test (ACT), asthma control questionnaire (ACQ) scores, and the inhaled corticosteroid (ICS) dose were recorded. A generalized linear mixed model was used to adjust for potential confounders. Results A total of 492 patients with asthma were included in this study. Of these patients, 13.0% were current smokers, 9.6% were former smokers, and 77.4% were never smokers. Compared with never smokers, the current and former smokers had a longer duration of asthma; lower ACT scores, FEV1, FEV1%pred, and FEV1/FVC; and higher ACQ scores, IgE, FeNO, blood eosinophils, and ICS dose (p < .05). In addition, the patients exposed to biomass alone were older; had higher exacerbation in the past year; a longer duration of asthma; and lower FEV1, FEV1%pred, FEV1/FVC, IgE, and FeNO compared with smoking or occupational exposure alone. Compared with smoking exposure alone, patients with occupational exposure alone had a longer duration of asthma and lower FEV1, FEV1%pred, FVC, IgE, FeNO, and ICS dose (p < .05). Conclusions There are significant differences in the clinical characteristics of patients with asthma depending on the smoking status. In addition, significant differences also observed among smoking, biomass, and occupational exposure.https://doi.org/10.1002/iid3.923asthmabiomassoccupational exposuresmoking |
| spellingShingle | Laiheng Luo The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study Immunity, Inflammation and Disease asthma biomass occupational exposure smoking |
| title | The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study |
| title_full | The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study |
| title_fullStr | The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study |
| title_full_unstemmed | The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study |
| title_short | The clinical characteristics of patients with asthma exposed to different environmental risk factors: A cross‐sectional study |
| title_sort | clinical characteristics of patients with asthma exposed to different environmental risk factors a cross sectional study |
| topic | asthma biomass occupational exposure smoking |
| url | https://doi.org/10.1002/iid3.923 |
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