State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy
Gadolinium neutron capture therapy(GdNCT) is an innovative treatment that exert damage on tumor cells based on the capture reaction between thermal neutron and gadolinium. In comparison with other types of neutron capture therapy(NCT), gadolinium has the highest thermal capture cross section of any...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Nuclear and Radiochemistry
2022-06-01
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| Series: | He huaxue yu fangshe huaxue |
| Subjects: | |
| Online Access: | http://www.jnrc.org.cn/CN/10.7538/hhx.2022.YX.2021086 |
| _version_ | 1827292065056161792 |
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| author | HAN Yi CUI Da-qing LI Ji-yuan LIU Zhi-bo |
| author_facet | HAN Yi CUI Da-qing LI Ji-yuan LIU Zhi-bo |
| author_sort | HAN Yi |
| collection | DOAJ |
| description | Gadolinium neutron capture therapy(GdNCT) is an innovative treatment that exert damage on tumor cells based on the capture reaction between thermal neutron and gadolinium. In comparison with other types of neutron capture therapy(NCT), gadolinium has the highest thermal capture cross section of any natural elements. Gadolinium-based agents are widely used in magnetic resonance imaging(MRI) as contrast agents. The improvements of multiple gadolinium-based agents have been applied to enhance therapeutic efficacy of GdNCT. In this review, principles of gadolinium neutron capture therapy were studied and diverse strategies to improve therapeutic efficacy of gadolinium-based agents were summarized. Giving a perspective on GdNCT to prompt its clinical use. |
| first_indexed | 2024-04-24T12:50:26Z |
| format | Article |
| id | doaj.art-cf0adcc410c143e18c6092fcd22b3f6d |
| institution | Directory Open Access Journal |
| issn | 0253-9950 |
| language | zho |
| last_indexed | 2024-04-24T12:50:26Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Office of Journal of Nuclear and Radiochemistry |
| record_format | Article |
| series | He huaxue yu fangshe huaxue |
| spelling | doaj.art-cf0adcc410c143e18c6092fcd22b3f6d2024-04-06T05:48:45ZzhoEditorial Office of Journal of Nuclear and RadiochemistryHe huaxue yu fangshe huaxue0253-99502022-06-0144333934610.7538/hhx.2022.YX.2021086State and Progress of Gadolinium-Based Agents for Neutron Capture TherapyHAN Yi0CUI Da-qing1LI Ji-yuan2LIU Zhi-bo3China Institute of Atomic EnergyDepartment of Materials and Environmental Chemistry, Stockholms UniversityChina Institute of Atomic EnergyCollege of Chemistry and Molecular Engineering, Peking UniversityGadolinium neutron capture therapy(GdNCT) is an innovative treatment that exert damage on tumor cells based on the capture reaction between thermal neutron and gadolinium. In comparison with other types of neutron capture therapy(NCT), gadolinium has the highest thermal capture cross section of any natural elements. Gadolinium-based agents are widely used in magnetic resonance imaging(MRI) as contrast agents. The improvements of multiple gadolinium-based agents have been applied to enhance therapeutic efficacy of GdNCT. In this review, principles of gadolinium neutron capture therapy were studied and diverse strategies to improve therapeutic efficacy of gadolinium-based agents were summarized. Giving a perspective on GdNCT to prompt its clinical use.http://www.jnrc.org.cn/CN/10.7538/hhx.2022.YX.2021086gdnctncttargeted therapy |
| spellingShingle | HAN Yi CUI Da-qing LI Ji-yuan LIU Zhi-bo State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy He huaxue yu fangshe huaxue gdnct nct targeted therapy |
| title | State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
| title_full | State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
| title_fullStr | State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
| title_full_unstemmed | State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
| title_short | State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
| title_sort | state and progress of gadolinium based agents for neutron capture therapy |
| topic | gdnct nct targeted therapy |
| url | http://www.jnrc.org.cn/CN/10.7538/hhx.2022.YX.2021086 |
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