Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen

Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen

IntroductionIn de-novo kidney transplantation, the CTLA4-Ig fusion protein belatacept is associated with improved graft function but also an increased risk of acute rejection compared to calcineurin inhibitor therapy. The combination with a second costimulation blocker could potentially improve outc...

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Bibliographic Details
Main Authors: Lukas W. Unger, Moritz Muckenhuber, Benedikt Mahr, Christoph Schwarz, Nina Pilat, Nicolas Granofszky, Heinz Regele, Thomas Wekerle
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
costimulation blockade
CTLA4Ig
CD40L blockade
murine cardiac allotransplant
transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060576/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060576/full

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