Multiple CH/π Interactions Maintain the Binding of Aflatoxin B1 in the Active Cavity of Human Cytochrome P450 1A2

Multiple CH/π Interactions Maintain the Binding of Aflatoxin B1 in the Active Cavity of Human Cytochrome P450 1A2

Human cytochrome P450 1A2 (CYP1A2) is one of the key CYPs that activate aflatoxin B1 (AFB1), a notorious mycotoxin, into carcinogenic exo-8,9-epoxides (AFBO) in the liver. Although the structure of CYP1A2 is available, the mechanism of CYP1A2-specific binding to AFB1 has not been fully clarified. In...

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Bibliographic Details
Main Authors: Jun Wu, Sisi Zhu, Yunbo Wu, Tianqing Jiang, Lingling Wang, Jun Jiang, Jikai Wen, Yiqun Deng
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Toxins
Subjects:
CH/π interaction
cytochrome P450
CYP1A2
aflatoxin
specificity
Online Access:http://www.mdpi.com/2072-6651/11/3/158

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