Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

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Summary: Suppression of premature termination codons (PTCs) by translational readthrough is a promising strategy to treat a wide variety of severe genetic diseases caused by nonsense mutations. Here, we present two potent readthrough promoters—NVS1.1 and NVS2.1—that restore substantial levels of fun...

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Bibliographic Details
Main Authors: Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723010677

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http://www.sciencedirect.com/science/article/pii/S2211124723010677

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