Targeted therapy for pediatric central nervous system tumors harboring mutagenic tropomyosin receptor kinases

Targeted therapy for pediatric central nervous system tumors harboring mutagenic tropomyosin receptor kinases

The family of the neurotrophic tyrosine kinase receptor (NTRK) gene encodes for members of the tropomyosin receptor kinase (TRK) family. Rearrangements involving NTRK1/2/3 are rare oncogenic factors reported with variable frequencies in an extensive range of cancers in pediatrics and adult populatio...

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Bibliographic Details
Main Authors: Selene Cipri, Francesco Fabozzi, Giada Del Baldo, Giuseppe Maria Milano, Luigi Boccuto, Andrea Carai, Angela Mastronuzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
pediatric tumors
central nervous system tumors
tropomyosin receptor kinases
NTRK
gene fusions
point mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1235794/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1235794/full

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