Prognostic criteria of chronic myeloid leukemia by changes platelets sizes
In order to identify specific changes in the size of platelets in patients with chronic myeloid leukemia (CML) and assess possibility of their use as prognostic criteria for disease progression peripheral blood of 62 patients with CML was examined. The study was carried out by an automatic hematolog...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2016-03-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2016/N1/35-39.pdf |
| _version_ | 1819105593803145216 |
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| author | Shorop Y.V. Tymchenko A.C. |
| author_facet | Shorop Y.V. Tymchenko A.C. |
| author_sort | Shorop Y.V. |
| collection | DOAJ |
| description | In order to identify specific changes in the size of platelets in patients with chronic myeloid leukemia (CML) and assess possibility of their use as prognostic criteria for disease progression peripheral blood of 62 patients with CML was examined. The study was carried out by an automatic hematology analyzer and method of computer image analysis on micrographs of peripheral blood smears. CML patients showed an increase in mean platelet volume (parametr MPV) and the percentage of large platelets (parameter P-LCR). Measurement of platelet digital micrographs, carried out in parallel, showed an increase of variability of their size. Analysis of characteristic curves of the specificity/sensitivity showed the possibility of using the coefficient of variation and standard deviation of the natural logarithm of platelets in areas of the peripheral blood smear as a predictor of progression of CML in blast crisis phase. |
| first_indexed | 2024-12-22T02:24:43Z |
| format | Article |
| id | doaj.art-cf12614b4bc848ff9e3fb6faa295f4ee |
| institution | Directory Open Access Journal |
| issn | 2307-0404 2307-0404 |
| language | English |
| last_indexed | 2024-12-22T02:24:43Z |
| publishDate | 2016-03-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-cf12614b4bc848ff9e3fb6faa295f4ee2022-12-21T18:42:02ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042016-03-012113539Prognostic criteria of chronic myeloid leukemia by changes platelets sizesShorop Y.V.0Tymchenko A.C.1SI «Iinstitute of haematology and transfusiology NAMS Ukraine» SI «Iinstitute of haematology and transfusiology NAMS Ukraine» In order to identify specific changes in the size of platelets in patients with chronic myeloid leukemia (CML) and assess possibility of their use as prognostic criteria for disease progression peripheral blood of 62 patients with CML was examined. The study was carried out by an automatic hematology analyzer and method of computer image analysis on micrographs of peripheral blood smears. CML patients showed an increase in mean platelet volume (parametr MPV) and the percentage of large platelets (parameter P-LCR). Measurement of platelet digital micrographs, carried out in parallel, showed an increase of variability of their size. Analysis of characteristic curves of the specificity/sensitivity showed the possibility of using the coefficient of variation and standard deviation of the natural logarithm of platelets in areas of the peripheral blood smear as a predictor of progression of CML in blast crisis phase.http://medpers.dsma.dp.ua/issues/2016/N1/35-39.pdfchronic myeloid leukemiablast crisisplateletsautomatic hematology analyzerplatelet indicesmorphometry |
| spellingShingle | Shorop Y.V. Tymchenko A.C. Prognostic criteria of chronic myeloid leukemia by changes platelets sizes Medičnì Perspektivi chronic myeloid leukemia blast crisis platelets automatic hematology analyzer platelet indices morphometry |
| title | Prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| title_full | Prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| title_fullStr | Prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| title_full_unstemmed | Prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| title_short | Prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| title_sort | prognostic criteria of chronic myeloid leukemia by changes platelets sizes |
| topic | chronic myeloid leukemia blast crisis platelets automatic hematology analyzer platelet indices morphometry |
| url | http://medpers.dsma.dp.ua/issues/2016/N1/35-39.pdf |
| work_keys_str_mv | AT shoropyv prognosticcriteriaofchronicmyeloidleukemiabychangesplateletssizes AT tymchenkoac prognosticcriteriaofchronicmyeloidleukemiabychangesplateletssizes |