Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy
Imaging plays a vital role in detecting the recurrence of prostate cancer (PCa) to guide the choice of salvage therapy. Gallium-68 prostate-specific membrane antigen positron-emission tomography/computed tomography (<sup>68</sup>Ga-PSMA-11 PET/CT) is useful for detecting PCa recurrence....
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3883 |
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| author | Ismaheel O. Lawal Thabo Lengana Gbenga O. Popoola Akintunde T. Orunmuyi Mankgopo M. Kgatle Kgomotso M. G. Mokoala Mike M. Sathekge |
| author_facet | Ismaheel O. Lawal Thabo Lengana Gbenga O. Popoola Akintunde T. Orunmuyi Mankgopo M. Kgatle Kgomotso M. G. Mokoala Mike M. Sathekge |
| author_sort | Ismaheel O. Lawal |
| collection | DOAJ |
| description | Imaging plays a vital role in detecting the recurrence of prostate cancer (PCa) to guide the choice of salvage therapy. Gallium-68 prostate-specific membrane antigen positron-emission tomography/computed tomography (<sup>68</sup>Ga-PSMA-11 PET/CT) is useful for detecting PCa recurrence. We assessed the pattern of PCa recurrence stratified by serum prostate-specific antigen level and type of primary local treatment in men with biochemical recurrence (BCR) after primary local therapy with radical prostatectomy or external beam radiotherapy (EBRT) using <sup>68</sup>Ga-PSMA-11 PET/CT. We reviewed patients imaged with <sup>68</sup>Ga-PSMA-11 PET/CT for the localization of the site of PCa recurrence. We determined the site and number of lesions due to PCa recurrence at different PSA levels. A total of 247 men (mean age of 65.72 ± 7.51 years and median PSA of 2.70 ng/mL (IQR = 0.78–5.80)) were included. <sup>68</sup>Ga-PSMA-11 PET/CT detected the site of recurrence in 81.4% of patients with a median number of lesions per patient of 1 (range = 1–5). <sup>68</sup>Ga-PSMA-11 PET/CT positivity was 43.6%, 75.7%, 83.3%, 90.0%, and 95.8% at PSA levels of <0.5, 0.5–1.0., 1.1–2.0, 2.1–5.0, and 5.0–10.0, respectively. The most common site of recurrence was in the prostate gland/bed at all PSA levels. Pelvic, extra-pelvic, and combined pelvic and extra-pelvic sites of recurrence were seen in 118, 50, and 33 patients, respectively. The risk of extra-pelvic recurrence increases with rising PSA levels. <sup>68</sup>Ga-PSMA-11 PET/CT has a high lesion detection rate for biochemical recurrence of PCa in patients previously treated with primary local therapy. |
| first_indexed | 2024-03-10T08:09:23Z |
| format | Article |
| id | doaj.art-cf1619ee82744f4fb5d66430c251adc2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:09:23Z |
| publishDate | 2021-08-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cf1619ee82744f4fb5d66430c251adc22023-11-22T10:48:50ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017388310.3390/jcm10173883Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local TherapyIsmaheel O. Lawal0Thabo Lengana1Gbenga O. Popoola2Akintunde T. Orunmuyi3Mankgopo M. Kgatle4Kgomotso M. G. Mokoala5Mike M. Sathekge6Department of Nuclear Medicine, University of Pretoria, Pretoria 0001, South AfricaDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0001, South AfricaDepartment of Epidemiology and Community Health, University of Ilorin, Ilorin 240102, NigeriaDepartment of Nuclear Medicine, University of Ibadan, Ibadan 200284, NigeriaDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0001, South AfricaDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0001, South AfricaDepartment of Nuclear Medicine, University of Pretoria, Pretoria 0001, South AfricaImaging plays a vital role in detecting the recurrence of prostate cancer (PCa) to guide the choice of salvage therapy. Gallium-68 prostate-specific membrane antigen positron-emission tomography/computed tomography (<sup>68</sup>Ga-PSMA-11 PET/CT) is useful for detecting PCa recurrence. We assessed the pattern of PCa recurrence stratified by serum prostate-specific antigen level and type of primary local treatment in men with biochemical recurrence (BCR) after primary local therapy with radical prostatectomy or external beam radiotherapy (EBRT) using <sup>68</sup>Ga-PSMA-11 PET/CT. We reviewed patients imaged with <sup>68</sup>Ga-PSMA-11 PET/CT for the localization of the site of PCa recurrence. We determined the site and number of lesions due to PCa recurrence at different PSA levels. A total of 247 men (mean age of 65.72 ± 7.51 years and median PSA of 2.70 ng/mL (IQR = 0.78–5.80)) were included. <sup>68</sup>Ga-PSMA-11 PET/CT detected the site of recurrence in 81.4% of patients with a median number of lesions per patient of 1 (range = 1–5). <sup>68</sup>Ga-PSMA-11 PET/CT positivity was 43.6%, 75.7%, 83.3%, 90.0%, and 95.8% at PSA levels of <0.5, 0.5–1.0., 1.1–2.0, 2.1–5.0, and 5.0–10.0, respectively. The most common site of recurrence was in the prostate gland/bed at all PSA levels. Pelvic, extra-pelvic, and combined pelvic and extra-pelvic sites of recurrence were seen in 118, 50, and 33 patients, respectively. The risk of extra-pelvic recurrence increases with rising PSA levels. <sup>68</sup>Ga-PSMA-11 PET/CT has a high lesion detection rate for biochemical recurrence of PCa in patients previously treated with primary local therapy.https://www.mdpi.com/2077-0383/10/17/3883prostate cancerradical prostatectomyradiotherapybiochemical recurrencePSMAPET/CT |
| spellingShingle | Ismaheel O. Lawal Thabo Lengana Gbenga O. Popoola Akintunde T. Orunmuyi Mankgopo M. Kgatle Kgomotso M. G. Mokoala Mike M. Sathekge Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy Journal of Clinical Medicine prostate cancer radical prostatectomy radiotherapy biochemical recurrence PSMA PET/CT |
| title | Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy |
| title_full | Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy |
| title_fullStr | Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy |
| title_full_unstemmed | Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy |
| title_short | Pattern of Prostate Cancer Recurrence Assessed by <sup>68</sup>Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy |
| title_sort | pattern of prostate cancer recurrence assessed by sup 68 sup ga psma 11 pet ct in men treated with primary local therapy |
| topic | prostate cancer radical prostatectomy radiotherapy biochemical recurrence PSMA PET/CT |
| url | https://www.mdpi.com/2077-0383/10/17/3883 |
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