Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling

Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling

Approximately 80% of breast cancer (BC) cases express the estrogen receptor (ER), and 30–40% of these cases acquire resistance to endocrine therapies over time. Hyperactivation of Akt is one of the mechanisms by which endocrine resistance is acquired. Apigenin (Api), a flavone found in several plant...

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Bibliographic Details
Main Authors: Thu Ha Pham, Yann Le Page, Frédéric Percevault, François Ferrière, Gilles Flouriot, Farzad Pakdel
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
endocrine resistance
ER
Akt
FOXM1
phytochemicals
Online Access:https://www.mdpi.com/1422-0067/22/1/470

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