Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy pa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/22/12531 |
| _version_ | 1797509956932468736 |
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| author | Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia |
| author_facet | Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia |
| author_sort | Herlinda Bonilla-Jaime |
| collection | DOAJ |
| description | Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life. |
| first_indexed | 2024-03-10T05:26:01Z |
| format | Article |
| id | doaj.art-cf19f6229bb84310906165b4a626cf41 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:01Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cf19f6229bb84310906165b4a626cf412023-11-22T23:43:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221253110.3390/ijms222212531Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic LinkHerlinda Bonilla-Jaime0Helena Zeleke1Asheebo Rojas2Claudia Espinosa-Garcia3Departamento de Biología de la Reproducción, Área de Biología Conductual y Reproductiva, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de Mexico CP 09340, MexicoNeuroscience and Behavioral Biology Program, College of Arts and Sciences, Emory University, Atlanta, GA 30322, USADepartment of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA 30322, USADepartment of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA 30322, USASleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life.https://www.mdpi.com/1422-0067/22/22/12531sleepseizuresepilepsyneuroinflammationneurodegeneration |
| spellingShingle | Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link International Journal of Molecular Sciences sleep seizures epilepsy neuroinflammation neurodegeneration |
| title | Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link |
| title_full | Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link |
| title_fullStr | Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link |
| title_full_unstemmed | Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link |
| title_short | Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link |
| title_sort | sleep disruption worsens seizures neuroinflammation as a potential mechanistic link |
| topic | sleep seizures epilepsy neuroinflammation neurodegeneration |
| url | https://www.mdpi.com/1422-0067/22/22/12531 |
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