Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture

Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture

In chickens, γδ T cells represent a large fraction of peripheral T cells; however, their function remains largely unknown. Here, we describe the selective in vitro expansion of γδ T cells from total splenocytes by stimulation with the cytokines IL-2 and IL-12. Under these conditions, γδ T cells prol...

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Bibliographic Details
Main Authors: Antonia E. Linti, Thomas W. Göbel, Simon P. Früh
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
chicken γδ TCR
IL-2
IL-12
in vitro culture
γδ T cell subsets
TCR repertoire analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325024/full

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