Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis
Abstract Large peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed during embryonic life, developmentally and functionally confined to the peritoneal cavity. LPMs provide the first line of defense against life‐threatening pathologies of the peritoneal cavity, such as ab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202206617 |
| _version_ | 1827966922323394560 |
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| author | Carlos Ardavín Natalia Alvarez‐Ladrón Margarita Ferriz Alejandra Gutiérrez‐González Adrián Vega‐Pérez |
| author_facet | Carlos Ardavín Natalia Alvarez‐Ladrón Margarita Ferriz Alejandra Gutiérrez‐González Adrián Vega‐Pérez |
| author_sort | Carlos Ardavín |
| collection | DOAJ |
| description | Abstract Large peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed during embryonic life, developmentally and functionally confined to the peritoneal cavity. LPMs provide the first line of defense against life‐threatening pathologies of the peritoneal cavity, such as abdominal sepsis, peritoneal metastatic tumor growth, or peritoneal injuries caused by trauma, or abdominal surgery. Apart from their primary phagocytic function, reminiscent of primitive defense mechanisms sustained by coelomocytes in the coelomic cavity of invertebrates, LPMs fulfill an essential homeostatic function by achieving an efficient clearance of apoptotic, that is crucial for the maintenance of self‐tolerance. Research performed over the last few years, in mice, has unveiled the mechanisms by which LPMs fulfill a crucial role in repairing peritoneal injuries and controlling microbial and parasitic infections, reflecting that the GATA6‐driven LPM transcriptional program can be modulated by extracellular signals associated with pathological conditions. In contrast, recent experimental evidence supports that peritoneal tumors can subvert LPM metabolism and function, leading to the acquisition of a tumor‐promoting potential. The remarkable functional plasticity of LPMs can be nevertheless exploited to revert tumor‐induced LPM protumor potential, providing the basis for the development of novel immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming. |
| first_indexed | 2024-04-09T17:57:17Z |
| format | Article |
| id | doaj.art-cf1b4a29502940b7ae12a26bc864ebda |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T17:57:17Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-cf1b4a29502940b7ae12a26bc864ebda2023-04-14T19:54:19ZengWileyAdvanced Science2198-38442023-04-011011n/an/a10.1002/advs.202206617Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor MetastasisCarlos Ardavín0Natalia Alvarez‐Ladrón1Margarita Ferriz2Alejandra Gutiérrez‐González3Adrián Vega‐Pérez4Departamento de Inmunología y Oncología Centro Nacional de Biotecnología/CSIC Darwin 3 Madrid 28049 SpainDepartamento de Inmunología y Oncología Centro Nacional de Biotecnología/CSIC Darwin 3 Madrid 28049 SpainDepartamento de Inmunología y Oncología Centro Nacional de Biotecnología/CSIC Darwin 3 Madrid 28049 SpainDepartamento de Inmunología y Oncología Centro Nacional de Biotecnología/CSIC Darwin 3 Madrid 28049 SpainDepartamento de Inmunología y Oncología Centro Nacional de Biotecnología/CSIC Darwin 3 Madrid 28049 SpainAbstract Large peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed during embryonic life, developmentally and functionally confined to the peritoneal cavity. LPMs provide the first line of defense against life‐threatening pathologies of the peritoneal cavity, such as abdominal sepsis, peritoneal metastatic tumor growth, or peritoneal injuries caused by trauma, or abdominal surgery. Apart from their primary phagocytic function, reminiscent of primitive defense mechanisms sustained by coelomocytes in the coelomic cavity of invertebrates, LPMs fulfill an essential homeostatic function by achieving an efficient clearance of apoptotic, that is crucial for the maintenance of self‐tolerance. Research performed over the last few years, in mice, has unveiled the mechanisms by which LPMs fulfill a crucial role in repairing peritoneal injuries and controlling microbial and parasitic infections, reflecting that the GATA6‐driven LPM transcriptional program can be modulated by extracellular signals associated with pathological conditions. In contrast, recent experimental evidence supports that peritoneal tumors can subvert LPM metabolism and function, leading to the acquisition of a tumor‐promoting potential. The remarkable functional plasticity of LPMs can be nevertheless exploited to revert tumor‐induced LPM protumor potential, providing the basis for the development of novel immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming.https://doi.org/10.1002/advs.202206617macrophagesmonocyte‐derived macrophagesperitoneal cavityperitoneal injuryperitoneal metastasisperitoneal sepsis |
| spellingShingle | Carlos Ardavín Natalia Alvarez‐Ladrón Margarita Ferriz Alejandra Gutiérrez‐González Adrián Vega‐Pérez Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis Advanced Science macrophages monocyte‐derived macrophages peritoneal cavity peritoneal injury peritoneal metastasis peritoneal sepsis |
| title | Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis |
| title_full | Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis |
| title_fullStr | Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis |
| title_full_unstemmed | Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis |
| title_short | Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis |
| title_sort | mouse tissue resident peritoneal macrophages in homeostasis repair infection and tumor metastasis |
| topic | macrophages monocyte‐derived macrophages peritoneal cavity peritoneal injury peritoneal metastasis peritoneal sepsis |
| url | https://doi.org/10.1002/advs.202206617 |
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