Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study
BackgroundThe current indications based on the clinicopathological parameters for predicting the need for surgery in neonatal necrotizing enterocolitis (NEC) are still limited. This study retrospectively analyzes the characteristics of neonatal NEC and aims to identify the risk factors for surgical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.889321/full |
| _version_ | 1798042962760826880 |
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| author | Lei Yu Chao Liu Qingjing Du Lishuang Ma |
| author_facet | Lei Yu Chao Liu Qingjing Du Lishuang Ma |
| author_sort | Lei Yu |
| collection | DOAJ |
| description | BackgroundThe current indications based on the clinicopathological parameters for predicting the need for surgery in neonatal necrotizing enterocolitis (NEC) are still limited. This study retrospectively analyzes the characteristics of neonatal NEC and aims to identify the risk factors for surgical intervention in NEC.MethodsData of the NEC cases from 2015 to 2019 were collected from our institution and divided into two groups: surgical group (n = 41) and conservative treatment group (n = 143). Clinical, physical, and laboratory measures were analyzed by univariate analysis and multivariate logistic regression. The diagnostic values and receiver operative characteristic (ROC) curve were used for the assessment.ResultsUnivariate analysis identified significant differences between the surgical group and the conservative group in a series of clinical, physical, and laboratory measures (all p < 0.05). The results of multivariate logistic regression analysis showed that procalcitonin (adjusted OR: 167.1, 95% CI, 3.585–7,788.758, p = 0.009) and gestational age (adjusted OR: 0.85, 95% CI, 0.77–0.94, p = 0.001) were independent surgical indications for NEC. The results from ROC curve and diagnosis values demonstrated that procalcitonin [the area under the curve (AUC) = 0.864], CRP (AUC = 0.783) and fibrinogen (AUC = 0.720) had good predictive performance for surgical NEC.ConclusionsThe level of procalcitonin and gestational age were found to be independent surgical indications for neonates with NEC. |
| first_indexed | 2024-04-11T22:42:49Z |
| format | Article |
| id | doaj.art-cf202755189340db8e399dbb18478259 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T22:42:49Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-cf202755189340db8e399dbb184782592022-12-22T03:58:55ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-05-01910.3389/fsurg.2022.889321889321Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective StudyLei Yu0Chao Liu1Qingjing Du2Lishuang Ma3Children's Hospital, Capital Institute of Pediatrics, Department of Hospital Infection Administrative, Beijing, ChinaChildren's Hospital, Capital Institute of Pediatrics, Department of Neonatal General Surgery, Beijing, ChinaChildren's Hospital, Capital Institute of Pediatrics, Department of Hospital Infection Administrative, Beijing, ChinaChildren's Hospital, Capital Institute of Pediatrics, Department of Neonatal General Surgery, Beijing, ChinaBackgroundThe current indications based on the clinicopathological parameters for predicting the need for surgery in neonatal necrotizing enterocolitis (NEC) are still limited. This study retrospectively analyzes the characteristics of neonatal NEC and aims to identify the risk factors for surgical intervention in NEC.MethodsData of the NEC cases from 2015 to 2019 were collected from our institution and divided into two groups: surgical group (n = 41) and conservative treatment group (n = 143). Clinical, physical, and laboratory measures were analyzed by univariate analysis and multivariate logistic regression. The diagnostic values and receiver operative characteristic (ROC) curve were used for the assessment.ResultsUnivariate analysis identified significant differences between the surgical group and the conservative group in a series of clinical, physical, and laboratory measures (all p < 0.05). The results of multivariate logistic regression analysis showed that procalcitonin (adjusted OR: 167.1, 95% CI, 3.585–7,788.758, p = 0.009) and gestational age (adjusted OR: 0.85, 95% CI, 0.77–0.94, p = 0.001) were independent surgical indications for NEC. The results from ROC curve and diagnosis values demonstrated that procalcitonin [the area under the curve (AUC) = 0.864], CRP (AUC = 0.783) and fibrinogen (AUC = 0.720) had good predictive performance for surgical NEC.ConclusionsThe level of procalcitonin and gestational age were found to be independent surgical indications for neonates with NEC.https://www.frontiersin.org/articles/10.3389/fsurg.2022.889321/fulllaboratory examinationnecrotizing enterocolitisoperation timephysical examinationretrospective study |
| spellingShingle | Lei Yu Chao Liu Qingjing Du Lishuang Ma Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study Frontiers in Surgery laboratory examination necrotizing enterocolitis operation time physical examination retrospective study |
| title | Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study |
| title_full | Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study |
| title_fullStr | Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study |
| title_full_unstemmed | Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study |
| title_short | Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study |
| title_sort | predictive factors for surgical intervention in neonates with necrotizing enterocolitis a retrospective study |
| topic | laboratory examination necrotizing enterocolitis operation time physical examination retrospective study |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.889321/full |
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