Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum
Five new pregnane-type steroids, sclerosteroids J–N (1–5), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/6/1853 |
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| author | Jyh-Horng Sheu Chang-Feng Dai Yang-Chang Wu Chih-Hua Chao Zhi-Hong Wen Chi-Hsin Hsu Hui-Yu Fang |
| author_facet | Jyh-Horng Sheu Chang-Feng Dai Yang-Chang Wu Chih-Hua Chao Zhi-Hong Wen Chi-Hsin Hsu Hui-Yu Fang |
| author_sort | Jyh-Horng Sheu |
| collection | DOAJ |
| description | Five new pregnane-type steroids, sclerosteroids J–N (1–5), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells. |
| first_indexed | 2024-12-10T07:51:19Z |
| format | Article |
| id | doaj.art-cf202c6a33d241b29be3b3fcbfe3353f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T07:51:19Z |
| publishDate | 2013-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-cf202c6a33d241b29be3b3fcbfe3353f2022-12-22T01:57:02ZengMDPI AGMarine Drugs1660-33972013-05-011161853186510.3390/md11061853Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimumJyh-Horng SheuChang-Feng DaiYang-Chang WuChih-Hua ChaoZhi-Hong WenChi-Hsin HsuHui-Yu FangFive new pregnane-type steroids, sclerosteroids J–N (1–5), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.http://www.mdpi.com/1660-3397/11/6/1853soft coralScleronephthya gracillimumcytotoxicity activityanti-inflammatory activity |
| spellingShingle | Jyh-Horng Sheu Chang-Feng Dai Yang-Chang Wu Chih-Hua Chao Zhi-Hong Wen Chi-Hsin Hsu Hui-Yu Fang Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum Marine Drugs soft coral Scleronephthya gracillimum cytotoxicity activity anti-inflammatory activity |
| title | Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum |
| title_full | Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum |
| title_fullStr | Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum |
| title_full_unstemmed | Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum |
| title_short | Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum |
| title_sort | cytotoxic and anti inflammatory metabolites from the soft coral scleronephthya gracillimum |
| topic | soft coral Scleronephthya gracillimum cytotoxicity activity anti-inflammatory activity |
| url | http://www.mdpi.com/1660-3397/11/6/1853 |
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