Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adap...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/59422 |
| _version_ | 1818024013036781568 |
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| author | Henri Leinonen Nguyen C Pham Taylor Boyd Johanes Santoso Krzysztof Palczewski Frans Vinberg |
| author_facet | Henri Leinonen Nguyen C Pham Taylor Boyd Johanes Santoso Krzysztof Palczewski Frans Vinberg |
| author_sort | Henri Leinonen |
| collection | DOAJ |
| description | Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in bipolar cells expected to support normal vision. Whether such homeostatic plasticity occurs during progressive photoreceptor degenerative disease to help maintain normal visual behavior is unknown. We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. We show robust modulation of the retinal transcriptomic network, reminiscent of the neurodevelopmental state, and potentiation of rod – rod bipolar cell signaling following rod photoreceptor degeneration. Additionally, we found highly sensitive night vision in P23H mice even when more than half of the rod photoreceptors were lost. These results suggest retinal adaptation leading to persistent visual function during photoreceptor degenerative disease. |
| first_indexed | 2024-12-10T03:53:27Z |
| format | Article |
| id | doaj.art-cf20828d37544622bc3ae6e18e0ed555 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T03:53:27Z |
| publishDate | 2020-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-cf20828d37544622bc3ae6e18e0ed5552022-12-22T02:03:11ZengeLife Sciences Publications LtdeLife2050-084X2020-09-01910.7554/eLife.59422Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative diseaseHenri Leinonen0https://orcid.org/0000-0002-0388-832XNguyen C Pham1Taylor Boyd2Johanes Santoso3Krzysztof Palczewski4https://orcid.org/0000-0002-0788-545XFrans Vinberg5https://orcid.org/0000-0003-3439-4979Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United StatesJohn A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United StatesJohn A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United StatesGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United StatesGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United States; Departments of Physiology and Biophysics, and Chemistry, University of California, Irvine, Irvine, United StatesJohn A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United StatesNeuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in bipolar cells expected to support normal vision. Whether such homeostatic plasticity occurs during progressive photoreceptor degenerative disease to help maintain normal visual behavior is unknown. We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. We show robust modulation of the retinal transcriptomic network, reminiscent of the neurodevelopmental state, and potentiation of rod – rod bipolar cell signaling following rod photoreceptor degeneration. Additionally, we found highly sensitive night vision in P23H mice even when more than half of the rod photoreceptors were lost. These results suggest retinal adaptation leading to persistent visual function during photoreceptor degenerative disease.https://elifesciences.org/articles/59422homeostatic plasticitysensory systemseyeretinaretinal degenerationvision |
| spellingShingle | Henri Leinonen Nguyen C Pham Taylor Boyd Johanes Santoso Krzysztof Palczewski Frans Vinberg Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease eLife homeostatic plasticity sensory systems eye retina retinal degeneration vision |
| title | Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| title_full | Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| title_fullStr | Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| title_full_unstemmed | Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| title_short | Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| title_sort | homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease |
| topic | homeostatic plasticity sensory systems eye retina retinal degeneration vision |
| url | https://elifesciences.org/articles/59422 |
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