Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review
The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and the risk of psychiatric sequelae and consequent mental disorders has increased among the general population, health care workers and patients with COVID-19. Achieving effective and widesprea...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223017973 |
| _version_ | 1797364326347046912 |
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| author | Ting Zhu Hui Liu Shiman Gao Ning Jiang Shuai Chen Weijie Xie |
| author_facet | Ting Zhu Hui Liu Shiman Gao Ning Jiang Shuai Chen Weijie Xie |
| author_sort | Ting Zhu |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and the risk of psychiatric sequelae and consequent mental disorders has increased among the general population, health care workers and patients with COVID-19. Achieving effective and widespread prevention of pandemic-related psychiatric sequelae to protect the mental health of the global population is a serious challenge. Salidroside, as a natural agent, has substantial pharmacological activity and health effects, exerts obvious neuroprotective effects, and may be effective in preventing and treating psychiatric sequelae and mental disorders resulting from stress stemming from the COVID-19 pandemic. Herein, we systematically summarise, analyse and discuss the therapeutic effects of salidroside in the prevention and treatment of psychiatric sequelae as well as its roles in preventing the progression of mental disorders, and fully clarify the potential of salidroside as a widely applicable agent for preventing mental disorders caused by stress; the mechanisms underlying the potential protective effects of salidroside are involved in the regulation of the oxidative stress, neuroinflammation, neural regeneration and cell apoptosis in the brain, the network homeostasis of neurotransmission, HPA axis and cholinergic system, and the improvement of synaptic plasticity. Notably, this review innovatively proposes that salidroside is a potential agent for treating stress-induced health issues during the COVID-19 pandemic and provides scientific evidence and a theoretical basis for the use of natural products to combat the current mental health crisis. |
| first_indexed | 2024-03-08T16:33:39Z |
| format | Article |
| id | doaj.art-cf20b5d2354b40eaadb79fc7d500c4f9 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:39Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cf20b5d2354b40eaadb79fc7d500c4f92024-01-06T04:37:52ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115999Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A reviewTing Zhu0Hui Liu1Shiman Gao2Ning Jiang3Shuai Chen4Weijie Xie5Institute of Neuroregeneration & Neurorehabilitation, Department of Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao 266071, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou, China; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, Guizhou, ChinaDepartment of Clinical Pharmacy, Women and Children’s Hospital, Qingdao University, Qingdao 266034, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China; Corresponding authors.School of Public Health, Wuhan University, Donghu Road No. 115, Wuchang District, Wuhan 430071, China; Corresponding authors.Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200122, China; Correspondence to: Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and the risk of psychiatric sequelae and consequent mental disorders has increased among the general population, health care workers and patients with COVID-19. Achieving effective and widespread prevention of pandemic-related psychiatric sequelae to protect the mental health of the global population is a serious challenge. Salidroside, as a natural agent, has substantial pharmacological activity and health effects, exerts obvious neuroprotective effects, and may be effective in preventing and treating psychiatric sequelae and mental disorders resulting from stress stemming from the COVID-19 pandemic. Herein, we systematically summarise, analyse and discuss the therapeutic effects of salidroside in the prevention and treatment of psychiatric sequelae as well as its roles in preventing the progression of mental disorders, and fully clarify the potential of salidroside as a widely applicable agent for preventing mental disorders caused by stress; the mechanisms underlying the potential protective effects of salidroside are involved in the regulation of the oxidative stress, neuroinflammation, neural regeneration and cell apoptosis in the brain, the network homeostasis of neurotransmission, HPA axis and cholinergic system, and the improvement of synaptic plasticity. Notably, this review innovatively proposes that salidroside is a potential agent for treating stress-induced health issues during the COVID-19 pandemic and provides scientific evidence and a theoretical basis for the use of natural products to combat the current mental health crisis.http://www.sciencedirect.com/science/article/pii/S0753332223017973Psychiatric sequelaeSalidrosideNeuroprotectionMental disorderNeuroinflammationBrain plasticity |
| spellingShingle | Ting Zhu Hui Liu Shiman Gao Ning Jiang Shuai Chen Weijie Xie Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review Biomedicine & Pharmacotherapy Psychiatric sequelae Salidroside Neuroprotection Mental disorder Neuroinflammation Brain plasticity |
| title | Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review |
| title_full | Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review |
| title_fullStr | Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review |
| title_full_unstemmed | Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review |
| title_short | Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review |
| title_sort | effect of salidroside on neuroprotection and psychiatric sequelae during the covid 19 pandemic a review |
| topic | Psychiatric sequelae Salidroside Neuroprotection Mental disorder Neuroinflammation Brain plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223017973 |
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