Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues
The data in this article is related to the research article entitled, “Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer” [1]. Overexpression of survivin induces resistance to various anticancer therapies s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-09-01
|
| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340915000852 |
| _version_ | 1828462233500254208 |
|---|---|
| author | Yi-Chao Lee Jun-Wei Lee Chi-Chen Huang Ming-Heng Wu Kuen-Haur Lee |
| author_facet | Yi-Chao Lee Jun-Wei Lee Chi-Chen Huang Ming-Heng Wu Kuen-Haur Lee |
| author_sort | Yi-Chao Lee |
| collection | DOAJ |
| description | The data in this article is related to the research article entitled, “Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer” [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance. |
| first_indexed | 2024-12-11T02:32:45Z |
| format | Article |
| id | doaj.art-cf21b5cdc482493bafed01b7857645c2 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T02:32:45Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-cf21b5cdc482493bafed01b7857645c22022-12-22T01:23:48ZengElsevierData in Brief2352-34092015-09-014C23523810.1016/j.dib.2015.05.017Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissuesYi-Chao Lee0Jun-Wei Lee1Chi-Chen Huang2Ming-Heng Wu3Kuen-Haur Lee4The PhD Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanThe PhD Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanThe PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, TaiwanThe data in this article is related to the research article entitled, “Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer” [1]. Overexpression of survivin induces resistance to various anticancer therapies such as chemotherapy and radiation therapy in colorectal cancer (CRC) cells. To determine significant correlations of biological functions/pathways with survivin, 4567 significant genes were analyzed from the GEO DataSet (GSE21815) of CRC and these were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathway Analysis (IPA) database. The data here present the most significant disease and disordered biological functions, significant molecular/cellular functions and significant categories in physiological development/system functions which were associated with CRC. The top 10 canonical signaling pathways associated with CRC were categorize in order based on the level of statistical significance.http://www.sciencedirect.com/science/article/pii/S2352340915000852 |
| spellingShingle | Yi-Chao Lee Jun-Wei Lee Chi-Chen Huang Ming-Heng Wu Kuen-Haur Lee Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues Data in Brief |
| title | Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| title_full | Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| title_fullStr | Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| title_full_unstemmed | Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| title_short | Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| title_sort | data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues |
| url | http://www.sciencedirect.com/science/article/pii/S2352340915000852 |
| work_keys_str_mv | AT yichaolee datasupportingtheidentificationofcompoundforinhibitionofsurvivinofcolorectalcancerbyusingingenuitypathwayanalysisofgeneexpressionprofilingofcolorectalcancertissues AT junweilee datasupportingtheidentificationofcompoundforinhibitionofsurvivinofcolorectalcancerbyusingingenuitypathwayanalysisofgeneexpressionprofilingofcolorectalcancertissues AT chichenhuang datasupportingtheidentificationofcompoundforinhibitionofsurvivinofcolorectalcancerbyusingingenuitypathwayanalysisofgeneexpressionprofilingofcolorectalcancertissues AT minghengwu datasupportingtheidentificationofcompoundforinhibitionofsurvivinofcolorectalcancerbyusingingenuitypathwayanalysisofgeneexpressionprofilingofcolorectalcancertissues AT kuenhaurlee datasupportingtheidentificationofcompoundforinhibitionofsurvivinofcolorectalcancerbyusingingenuitypathwayanalysisofgeneexpressionprofilingofcolorectalcancertissues |