Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age
Abstract Background Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors. Methods A co-twin control design was employed to test whether prenatal phtha...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-024-17946-8 |
| _version_ | 1797272922563280896 |
|---|---|
| author | Han Xiao Liqin Hu Tingting Tang Jufang Zhong Qiao Xu Xiaonan Cai Feiyan Xiang Pan Yang Hong Mei Aifen Zhou |
| author_facet | Han Xiao Liqin Hu Tingting Tang Jufang Zhong Qiao Xu Xiaonan Cai Feiyan Xiang Pan Yang Hong Mei Aifen Zhou |
| author_sort | Han Xiao |
| collection | DOAJ |
| description | Abstract Background Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors. Methods A co-twin control design was employed to test whether prenatal phthalate exposure was associated with children’s neurocognitive development. We collected information from 97 mother-twin pairs enrolled in the Wuhan Twin Birth Cohort between March 2016 and October 2018. Fourteen phthalate metabolites were measured in maternal urine collected at each trimester. Neurodevelopmental differences in twins at the age of two were examined as the outcome of interest. Multiple informant model was used to examine the covariate-adjusted associations of prenatal phthalate exposure with mental development index (MDI) and psychomotor development index (PDI) scores assessed at 2 years of age based on Bayley Scales of Infant Development (Second Edition). This model also helps to identify the exposure window of susceptibility. Results Maternal urinary levels of mono-2-ethyl-5-oxohexyl phthalate (MEOHP) (β = 1.91, 95% CI: 0.43, 3.39), mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (β = 1.56, 95% CI: 0.33, 2.79), and the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) (β = 1.85, 95% CI: 0.39, 3.31) during the first trimester showed the strongest and significant positive associations with intra-twin MDI difference. When stratified with twin chorionicity, the positive associations of monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), individual DEHP metabolites, and ∑DEHP exposure during pregnancy with intra-twin neurodevelopmental differences were more significant in monochorionic diamniotic (MCDA) twins than those in dichorionic diamniotic (DCDA) twins. Conclusions Neurodevelopmental differences in MCDA twins were strongly associated with prenatal phthalate exposure. Our findings warrant further confirmation in longitudinal studies with larger sample sizes. |
| first_indexed | 2024-03-07T14:37:16Z |
| format | Article |
| id | doaj.art-cf23c84644aa406a9cb26afc484e7e8d |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:37:16Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-cf23c84644aa406a9cb26afc484e7e8d2024-03-05T20:37:11ZengBMCBMC Public Health1471-24582024-02-0124111210.1186/s12889-024-17946-8Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of ageHan Xiao0Liqin Hu1Tingting Tang2Jufang Zhong3Qiao Xu4Xiaonan Cai5Feiyan Xiang6Pan Yang7Hong Mei8Aifen Zhou9Institute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyOperating Room, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Obstetrics, Wuhan Children’s Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science and TechnologyDelivery Room, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan UniversityInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors. Methods A co-twin control design was employed to test whether prenatal phthalate exposure was associated with children’s neurocognitive development. We collected information from 97 mother-twin pairs enrolled in the Wuhan Twin Birth Cohort between March 2016 and October 2018. Fourteen phthalate metabolites were measured in maternal urine collected at each trimester. Neurodevelopmental differences in twins at the age of two were examined as the outcome of interest. Multiple informant model was used to examine the covariate-adjusted associations of prenatal phthalate exposure with mental development index (MDI) and psychomotor development index (PDI) scores assessed at 2 years of age based on Bayley Scales of Infant Development (Second Edition). This model also helps to identify the exposure window of susceptibility. Results Maternal urinary levels of mono-2-ethyl-5-oxohexyl phthalate (MEOHP) (β = 1.91, 95% CI: 0.43, 3.39), mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (β = 1.56, 95% CI: 0.33, 2.79), and the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) (β = 1.85, 95% CI: 0.39, 3.31) during the first trimester showed the strongest and significant positive associations with intra-twin MDI difference. When stratified with twin chorionicity, the positive associations of monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), individual DEHP metabolites, and ∑DEHP exposure during pregnancy with intra-twin neurodevelopmental differences were more significant in monochorionic diamniotic (MCDA) twins than those in dichorionic diamniotic (DCDA) twins. Conclusions Neurodevelopmental differences in MCDA twins were strongly associated with prenatal phthalate exposure. Our findings warrant further confirmation in longitudinal studies with larger sample sizes.https://doi.org/10.1186/s12889-024-17946-8PhthalatesNeurodevelopmental differencesTwinsUrine |
| spellingShingle | Han Xiao Liqin Hu Tingting Tang Jufang Zhong Qiao Xu Xiaonan Cai Feiyan Xiang Pan Yang Hong Mei Aifen Zhou Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age BMC Public Health Phthalates Neurodevelopmental differences Twins Urine |
| title | Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| title_full | Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| title_fullStr | Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| title_full_unstemmed | Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| title_short | Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| title_sort | prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age |
| topic | Phthalates Neurodevelopmental differences Twins Urine |
| url | https://doi.org/10.1186/s12889-024-17946-8 |
| work_keys_str_mv | AT hanxiao prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT liqinhu prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT tingtingtang prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT jufangzhong prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT qiaoxu prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT xiaonancai prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT feiyanxiang prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT panyang prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT hongmei prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage AT aifenzhou prenatalphthalateexposureandneurodevelopmentaldifferencesintwinsat2yearsofage |