The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.740941/full |
| _version_ | 1818971759118909440 |
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| author | Meike Weis Sosan Burhany Alba Perez Ortiz Oliver Nowak Svetlana Hetjens Katrin Zahn Stefan Schoenberg Thomas Schaible Neysan Rafat |
| author_facet | Meike Weis Sosan Burhany Alba Perez Ortiz Oliver Nowak Svetlana Hetjens Katrin Zahn Stefan Schoenberg Thomas Schaible Neysan Rafat |
| author_sort | Meike Weis |
| collection | DOAJ |
| description | Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR).Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD).Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR.Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR. |
| first_indexed | 2024-12-20T14:57:28Z |
| format | Article |
| id | doaj.art-cf24052677124acb86d68d3f08061f89 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-20T14:57:28Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-cf24052677124acb86d68d3f08061f892022-12-21T19:36:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-12-01910.3389/fped.2021.740941740941The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic HerniaMeike Weis0Sosan Burhany1Alba Perez Ortiz2Oliver Nowak3Svetlana Hetjens4Katrin Zahn5Stefan Schoenberg6Thomas Schaible7Neysan Rafat8Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Obstetrics and Gynecology, University Medical Center Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Biomathematics and Medical Statistics, Medical Faculty Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Pediatric Surgery, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, GermanyDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, GermanyObjective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR).Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD).Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR.Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR.https://www.frontiersin.org/articles/10.3389/fped.2021.740941/fullcongenital diaphragmatic hernia (CDH)survivalchronic lung disease (CLD)extracorporeal membrane oxygenationO/E LHRneonate |
| spellingShingle | Meike Weis Sosan Burhany Alba Perez Ortiz Oliver Nowak Svetlana Hetjens Katrin Zahn Stefan Schoenberg Thomas Schaible Neysan Rafat The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia Frontiers in Pediatrics congenital diaphragmatic hernia (CDH) survival chronic lung disease (CLD) extracorporeal membrane oxygenation O/E LHR neonate |
| title | The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia |
| title_full | The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia |
| title_fullStr | The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia |
| title_full_unstemmed | The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia |
| title_short | The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia |
| title_sort | chest radiographic thoracic area can serve as a prediction marker for morbidity and mortality in infants with congenital diaphragmatic hernia |
| topic | congenital diaphragmatic hernia (CDH) survival chronic lung disease (CLD) extracorporeal membrane oxygenation O/E LHR neonate |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.740941/full |
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