Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease
Background: Gender differences exist in Parkinson′s disease (PD), both in clinical manifestations and response to medical treatment. We investigated whether gender differences occur in the clinical characteristics of patients selected for bilateral subthalamic nucleus deep brain stimulation (STN DBS...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=1;spage=66;epage=70;aulast=Chandran |
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| author | Shyambabu Chandran Syam Krishnan Ravi Mohan Rao S Gangadhara Sarma P Sankara Sarma Asha Kishore |
| author_facet | Shyambabu Chandran Syam Krishnan Ravi Mohan Rao S Gangadhara Sarma P Sankara Sarma Asha Kishore |
| author_sort | Shyambabu Chandran |
| collection | DOAJ |
| description | Background: Gender differences exist in Parkinson′s disease (PD), both in clinical manifestations and response to medical treatment. We investigated whether gender differences occur in the clinical characteristics of patients selected for bilateral subthalamic nucleus deep brain stimulation (STN DBS) or in the outcome when resource limits influence treatment choices made by patients. Materials and Methods: Fifty-one consecutive patients were evaluated 1 month before, and 12 months after bilateral STN DBS. All patients were rated using Unified Parkinson′s Disease Rating Scale, Parkinson′s Disease Quality of Life (PDQL) Scale, Addenbrooke′s Cognitive Examination and Beck Depression Inventory. Results: Pre-operative characteristics did not differ between the genders except for lower doses of drugs (P = 0.03), worse emotional scores in PDQL (P = 0.01) and worse depression (P = 0.03) in women. There was no gender difference in the surgical outcome, except a lesser reduction of dopaminergic drugs in women. Depression and quality of life (QOL) improved equally well in women and men. Conclusion: Bilateral STN DBS is equally efficacious in both genders as a treatment for motor complications of PD and for improving QOL. Women are likely to be undertreated because of more severe dyskinesia and may experience less emotional well-being, and could therefore potentially benefit from earlier surgical treatment. |
| first_indexed | 2024-12-11T01:05:13Z |
| format | Article |
| id | doaj.art-cf2432caf77a40efbcee95cc9b0be2cf |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-11T01:05:13Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-cf2432caf77a40efbcee95cc9b0be2cf2022-12-22T01:26:13ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492014-01-01171667010.4103/0972-2327.128557Gender influence on selection and outcome of deep brain stimulation for Parkinson′s diseaseShyambabu ChandranSyam KrishnanRavi Mohan RaoS Gangadhara SarmaP Sankara SarmaAsha KishoreBackground: Gender differences exist in Parkinson′s disease (PD), both in clinical manifestations and response to medical treatment. We investigated whether gender differences occur in the clinical characteristics of patients selected for bilateral subthalamic nucleus deep brain stimulation (STN DBS) or in the outcome when resource limits influence treatment choices made by patients. Materials and Methods: Fifty-one consecutive patients were evaluated 1 month before, and 12 months after bilateral STN DBS. All patients were rated using Unified Parkinson′s Disease Rating Scale, Parkinson′s Disease Quality of Life (PDQL) Scale, Addenbrooke′s Cognitive Examination and Beck Depression Inventory. Results: Pre-operative characteristics did not differ between the genders except for lower doses of drugs (P = 0.03), worse emotional scores in PDQL (P = 0.01) and worse depression (P = 0.03) in women. There was no gender difference in the surgical outcome, except a lesser reduction of dopaminergic drugs in women. Depression and quality of life (QOL) improved equally well in women and men. Conclusion: Bilateral STN DBS is equally efficacious in both genders as a treatment for motor complications of PD and for improving QOL. Women are likely to be undertreated because of more severe dyskinesia and may experience less emotional well-being, and could therefore potentially benefit from earlier surgical treatment.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=1;spage=66;epage=70;aulast=ChandranDeep brain stimulationgender differencesParkinson′s disease |
| spellingShingle | Shyambabu Chandran Syam Krishnan Ravi Mohan Rao S Gangadhara Sarma P Sankara Sarma Asha Kishore Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease Annals of Indian Academy of Neurology Deep brain stimulation gender differences Parkinson′s disease |
| title | Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease |
| title_full | Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease |
| title_fullStr | Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease |
| title_full_unstemmed | Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease |
| title_short | Gender influence on selection and outcome of deep brain stimulation for Parkinson′s disease |
| title_sort | gender influence on selection and outcome of deep brain stimulation for parkinson s disease |
| topic | Deep brain stimulation gender differences Parkinson′s disease |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=1;spage=66;epage=70;aulast=Chandran |
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