Activation of p38, p21, and NRF-2 Mediates Decreased Proliferation of Human Dental Pulp Stem Cells Cultured under 21% O2

Activation of p38, p21, and NRF-2 Mediates Decreased Proliferation of Human Dental Pulp Stem Cells Cultured under 21% O2

High rates of stem cell proliferation are important in regenerative medicine and in stem cell banking for clinical use. Ambient oxygen tensions (21% O2) are normally used for in vitro culture, but physiological levels in vivo range between 3% and 6% O2. We compared proliferation of human dental pulp...

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Bibliographic Details
Main Authors: Marya El Alami, Jose Viña-Almunia, Juan Gambini, Cristina Mas-Bargues, Richard C.M. Siow, Miguel Peñarrocha, Giovanni E. Mann, Consuelo Borrás, Jose Viña
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111400246X

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