The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress.

The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress.

PUFs are RNA binding proteins that promote mRNA deadenylation and decay and inhibit translation. Yeast Puf5 is the prototype for studying PUF-dependent gene repression. Puf5 binds to the Pop2 subunit of the Ccr4-Pop2-NOT mRNA deadenylase, recruiting the deadenylase and associated translational repre...

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Bibliographic Details
Main Authors: Ana Traven, Tricia L Lo, Trevor Lithgow, Jörg Heierhorst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2871046?pdf=render

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