Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology
The aim of study. To increase the efficiency of reproductive function restoration in women with infertility on the background of thyroid gland pathology, prevent miscarriage, reduce the incidence of gestational complications, improve perinatal outcomes and reduce neonatal morbidity. Study design. 2...
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| Format: | Article |
| Language: | English |
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Publishing House TRILIST
2017-10-01
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| Series: | Репродуктивная эндокринология |
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| Online Access: | http://reproduct-endo.com/article/view/117628 |
| _version_ | 1818250231385423872 |
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| author | Т. Г. Романенко О. І. Чайка |
| author_facet | Т. Г. Романенко О. І. Чайка |
| author_sort | Т. Г. Романенко |
| collection | DOAJ |
| description | The aim of study. To increase the efficiency of reproductive function restoration in women with infertility on the background of thyroid gland pathology, prevent miscarriage, reduce the incidence of gestational complications, improve perinatal outcomes and reduce neonatal morbidity.
Study design. 221 women with infertility on the background of thyroid pathology were examined. Patients were divided into two clinical groups. The group I consisted of 92 women with induced pregnancies (IB) who received pregravid preparation: oral Ogestan® micronutrient complex (potassium iodide in a daily dose of 150 μg, folic acid 400 mg, vitamin D 5 μg, omega-3 fatty acids 200 mg docosahexaenoic acid, vitamin E 12 mg), micronized progesterone (Utrogestan®) 200 mg in the II phase of the menstrual cycle was intravaginal. Group II (129 women) with IB did not receive pregravid preparation.
Results. In the group I 56 women (60.9%) became pregnant after induction of pregnancy, in the group II – 62 women (48.1%). The level of hormones in the serum showed the clinical effectiveness of pregravid preparation according to the method proposed by the authors. Thus, in pregnant women of group I low normal levels of TSH and high normal levels of free T4 were noted, which is a prognostically favorable index for the induction of ovulation. On the levels of progesterone and estradiol in pregnant women of group II, the stress of functioning of the mother-placenta-fetus system was noted, which led to a significantly high frequency of obstetric and perinatal complications. Analysis of the flow of pregnancy and childbirth in the group I showed a significantly lower frequency of a number of complications, which led to a significantly lower frequency of abdominal delivery (64.0%) and neonatal morbidity in the early neonatal period (14.8%).
Conclusion. The inclusion of the Ogestan® complex in the schemes of pregravid preparation of women with infertility on the background of pathology of the thyroid gland is an effective way to replace the deficiency of the most important micronutrients and can be recommended for practical use. |
| first_indexed | 2024-12-12T15:49:06Z |
| format | Article |
| id | doaj.art-cf27e4d2116a41bcba0dc955c316ad51 |
| institution | Directory Open Access Journal |
| issn | 2309-4117 2411-1295 |
| language | English |
| last_indexed | 2024-12-12T15:49:06Z |
| publishDate | 2017-10-01 |
| publisher | Publishing House TRILIST |
| record_format | Article |
| series | Репродуктивная эндокринология |
| spelling | doaj.art-cf27e4d2116a41bcba0dc955c316ad512022-12-22T00:19:41ZengPublishing House TRILISTРепродуктивная эндокринология2309-41172411-12952017-10-0137192510.18370/2309-4117.2017.37.19-25109009Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathologyТ. Г. Романенко0https://orcid.org/0000-0003-0157-6223О. І. Чайка1https://orcid.org/0000-0002-6834-9992P.L. Shupik National Medical Academy of the Postgraduate Education, UkraineP.L. Shupik National Medical Academy of the Postgraduate Education, UkraineThe aim of study. To increase the efficiency of reproductive function restoration in women with infertility on the background of thyroid gland pathology, prevent miscarriage, reduce the incidence of gestational complications, improve perinatal outcomes and reduce neonatal morbidity. Study design. 221 women with infertility on the background of thyroid pathology were examined. Patients were divided into two clinical groups. The group I consisted of 92 women with induced pregnancies (IB) who received pregravid preparation: oral Ogestan® micronutrient complex (potassium iodide in a daily dose of 150 μg, folic acid 400 mg, vitamin D 5 μg, omega-3 fatty acids 200 mg docosahexaenoic acid, vitamin E 12 mg), micronized progesterone (Utrogestan®) 200 mg in the II phase of the menstrual cycle was intravaginal. Group II (129 women) with IB did not receive pregravid preparation. Results. In the group I 56 women (60.9%) became pregnant after induction of pregnancy, in the group II – 62 women (48.1%). The level of hormones in the serum showed the clinical effectiveness of pregravid preparation according to the method proposed by the authors. Thus, in pregnant women of group I low normal levels of TSH and high normal levels of free T4 were noted, which is a prognostically favorable index for the induction of ovulation. On the levels of progesterone and estradiol in pregnant women of group II, the stress of functioning of the mother-placenta-fetus system was noted, which led to a significantly high frequency of obstetric and perinatal complications. Analysis of the flow of pregnancy and childbirth in the group I showed a significantly lower frequency of a number of complications, which led to a significantly lower frequency of abdominal delivery (64.0%) and neonatal morbidity in the early neonatal period (14.8%). Conclusion. The inclusion of the Ogestan® complex in the schemes of pregravid preparation of women with infertility on the background of pathology of the thyroid gland is an effective way to replace the deficiency of the most important micronutrients and can be recommended for practical use.http://reproduct-endo.com/article/view/117628thyroid pathologyinduced pregnancypregravid preparation |
| spellingShingle | Т. Г. Романенко О. І. Чайка Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology Репродуктивная эндокринология thyroid pathology induced pregnancy pregravid preparation |
| title | Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| title_full | Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| title_fullStr | Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| title_full_unstemmed | Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| title_short | Clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| title_sort | clinical efficacy of pregravid preparation in induced pregnancy on a background of thyroid gland pathology |
| topic | thyroid pathology induced pregnancy pregravid preparation |
| url | http://reproduct-endo.com/article/view/117628 |
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