Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts

Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts

The synovium secretes synovial fluid, but is also richly innervated with nociceptors and acts as a gateway between avascular joint tissues and the circulatory system. Resident fibroblast-like synoviocytes’ (FLS) calcium-activated potassium channels (KCa) change in activity in arthritis models and th...

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Bibliographic Details
Main Authors: Omar Haidar, Nathanael O’Neill, Caroline A. Staunton, Selvan Bavan, Fiona O’Brien, Sarah Zouggari, Umar Sharif, Ali Mobasheri, Kosuke Kumagai, Richard Barrett-Jolley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
TNFα
IL1β
inflammation
synovial fibroblast
ion channel
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00226/full

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