Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy
Purpose Red blood cell distribution width (RDW) evaluates the variation (size heterogeneity) in red blood cells. Elevated RDW has been identified as a predictor of poor functional outcomes for acute ischemic stroke. The association between elevated RDW level and poor functional outcome in stroke pat...
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| Format: | Article |
| Language: | English |
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Korean Society of Interventional Neuroradiology
2021-03-01
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| Series: | Neurointervention |
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| Online Access: | http://neurointervention.org/upload/pdf/neuroint-2020-00262.pdf |
| _version_ | 1797332306652823552 |
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| author | Cetin Kursad Akpinar Erdem Gurkaş Ozlem Aykac Zehra Uysal Atilla Ozcan Ozdemir |
| author_facet | Cetin Kursad Akpinar Erdem Gurkaş Ozlem Aykac Zehra Uysal Atilla Ozcan Ozdemir |
| author_sort | Cetin Kursad Akpinar |
| collection | DOAJ |
| description | Purpose Red blood cell distribution width (RDW) evaluates the variation (size heterogeneity) in red blood cells. Elevated RDW has been identified as a predictor of poor functional outcomes for acute ischemic stroke. The association between elevated RDW level and poor functional outcome in stroke patients undergoing mechanical thrombectomy has not been reported before. This study aims to investigate this relationship. Materials and Methods This was a multicenter retrospective study involving the prospectively and consecutively collected data of 205 adult stroke patients who underwent mechanical thrombectomy for anterior circulation large vessel occlusion (middle cerebral artery M1, anterior cerebral artery A1, tandem ICA-MCA, carotid T) between July 2017 and December 2019. RDW cut off levels were accepted as >16%. The effect of elevated RDW on poor functional outcome (modified Rankin scale 3–6) was investigated using bivariate and multivariate regression analysis. Results Elevated RDW was significantly associated with poor functional outcome in bivariate and multivariate analysis (odds ratio [OR] for RDW >16%, 2.078; 95% confidence interval [95% CI], 1.083–3.966; P=0.027 and OR for RDW >16%, 2.873; 95% CI, 1.342–6.151; P=0.007; respectively). Conclusion These findings suggest that elevated RDW may be an independent predictor of poor functional outcomes in ischemic stroke patients undergoing mechanical thrombectomy. |
| first_indexed | 2024-03-08T07:48:15Z |
| format | Article |
| id | doaj.art-cf29114a14374e8fb34f29e625a24fdf |
| institution | Directory Open Access Journal |
| issn | 2093-9043 2233-6273 |
| language | English |
| last_indexed | 2024-03-08T07:48:15Z |
| publishDate | 2021-03-01 |
| publisher | Korean Society of Interventional Neuroradiology |
| record_format | Article |
| series | Neurointervention |
| spelling | doaj.art-cf29114a14374e8fb34f29e625a24fdf2024-02-02T15:38:11ZengKorean Society of Interventional NeuroradiologyNeurointervention2093-90432233-62732021-03-01161343810.5469/neuroint.2020.00262302Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical ThrombectomyCetin Kursad Akpinar0Erdem Gurkaş1Ozlem Aykac2Zehra Uysal3Atilla Ozcan Ozdemir4 Stroke Center, Samsun Training and Research Hospital, Samsun, Turkey Stroke Center, Neurology Clinic, Lutfi Kırdar Training and Research Hospital, Istanbul, Turkey Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Interventional Neurology, Eskisehir Osmangazi University, Medical Faculty, Eskişehir, Turkey Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Interventional Neurology, Eskisehir Osmangazi University, Medical Faculty, Eskişehir, Turkey Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Interventional Neurology, Eskisehir Osmangazi University, Medical Faculty, Eskişehir, TurkeyPurpose Red blood cell distribution width (RDW) evaluates the variation (size heterogeneity) in red blood cells. Elevated RDW has been identified as a predictor of poor functional outcomes for acute ischemic stroke. The association between elevated RDW level and poor functional outcome in stroke patients undergoing mechanical thrombectomy has not been reported before. This study aims to investigate this relationship. Materials and Methods This was a multicenter retrospective study involving the prospectively and consecutively collected data of 205 adult stroke patients who underwent mechanical thrombectomy for anterior circulation large vessel occlusion (middle cerebral artery M1, anterior cerebral artery A1, tandem ICA-MCA, carotid T) between July 2017 and December 2019. RDW cut off levels were accepted as >16%. The effect of elevated RDW on poor functional outcome (modified Rankin scale 3–6) was investigated using bivariate and multivariate regression analysis. Results Elevated RDW was significantly associated with poor functional outcome in bivariate and multivariate analysis (odds ratio [OR] for RDW >16%, 2.078; 95% confidence interval [95% CI], 1.083–3.966; P=0.027 and OR for RDW >16%, 2.873; 95% CI, 1.342–6.151; P=0.007; respectively). Conclusion These findings suggest that elevated RDW may be an independent predictor of poor functional outcomes in ischemic stroke patients undergoing mechanical thrombectomy.http://neurointervention.org/upload/pdf/neuroint-2020-00262.pdfacute strokethrombectomyred blood cell distributionpoor functional outcome |
| spellingShingle | Cetin Kursad Akpinar Erdem Gurkaş Ozlem Aykac Zehra Uysal Atilla Ozcan Ozdemir Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy Neurointervention acute stroke thrombectomy red blood cell distribution poor functional outcome |
| title | Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy |
| title_full | Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy |
| title_fullStr | Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy |
| title_full_unstemmed | Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy |
| title_short | Elevated Red Blood Cell Distribution Width May Be a Novel Independent Predictor of Poor Functional Outcome in Patients Treated with Mechanical Thrombectomy |
| title_sort | elevated red blood cell distribution width may be a novel independent predictor of poor functional outcome in patients treated with mechanical thrombectomy |
| topic | acute stroke thrombectomy red blood cell distribution poor functional outcome |
| url | http://neurointervention.org/upload/pdf/neuroint-2020-00262.pdf |
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