Structural and functional properties of Grb2 SH2 dimer in CD28 binding

Structural and functional properties of Grb2 SH2 dimer in CD28 binding

Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein that plays a critical role in cellular signal transduction. It contains a central Src homology 2 (SH2) domain flanked by two Src homology 3 (SH3) domains. Binding of Grb2 SH2 to the cytoplasmic region of CD28, phosphorylated Tyr (pY...

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Bibliographic Details
Main Authors: Yuhi Hosoe, Nobutaka Numoto, Satomi Inaba, Shuhei Ogawa, Hisayuki Morii, Ryo Abe, Nobutoshi Ito, Masayuki Oda
Format: Article
Language:English
Published: The Biophysical Society of Japan 2019-02-01
Series:Biophysics and Physicobiology
Subjects:
binding kinetics
crystal structure
swapped dimer
thermal stability
Online Access:https://doi.org/10.2142/biophysico.16.0_80

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