Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging
Purpose: To illustrate the diagnosis and management of an atypical, cyst-like recurrence of retinoblastoma. Observations: A 4-month-old boy was diagnosed with Group B retinoblastoma in the right eye, consisting of a 10 x 9 × 3.6 mm retinal tumor temporal to the macula. He was treated with one sessio...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622004248 |
| _version_ | 1818513517815267328 |
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| author | Noy Ashkenazy J. Daniel Diaz Eric D. Hansen J. William Harbou Zelia M. Correa |
| author_facet | Noy Ashkenazy J. Daniel Diaz Eric D. Hansen J. William Harbou Zelia M. Correa |
| author_sort | Noy Ashkenazy |
| collection | DOAJ |
| description | Purpose: To illustrate the diagnosis and management of an atypical, cyst-like recurrence of retinoblastoma. Observations: A 4-month-old boy was diagnosed with Group B retinoblastoma in the right eye, consisting of a 10 x 9 × 3.6 mm retinal tumor temporal to the macula. He was treated with one session of intra-arterial ophthalmic artery chemotherapy using melphalan, followed by three sessions of diode laser transpupillary thermotherapy (TTT), after which complete tumor regression was achieved. 45 weeks after initial treatment, a cystic lesion was detected adjacent to superior margin of the regressed tumor scar. The differential diagnosis included pigment epithelial detachment, retinal gliosis, secondary retinoschisis, and local tumor recurrence. Multimodal imaging including OCT angiography confirmed the diagnosis of local recurrence manifesting as a vascularized cyst-like lesion. Two additional sessions of TTT achieved sustained tumor regression through 16 months of additional follow-up. Conclusions and Importance: Recurrence of retinoblastoma following chemotherapy typically manifests as enlargement of a previously regressed tumor, or seeding into the vitreous or subretinal space. An unusual cyst-like recurrence of retinoblastoma at the margin of a previously regressed tumor was diagnosed by multimodal imaging. Focal diode laser transpupillary thermotherapy was curative. |
| first_indexed | 2024-12-11T00:02:34Z |
| format | Article |
| id | doaj.art-cf2d44cff9074211bb1393a3b16ca0e6 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-11T00:02:34Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-cf2d44cff9074211bb1393a3b16ca0e62022-12-22T01:28:25ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-09-0127101678Cyst-like recurrence of retinoblastoma diagnosed by multimodal imagingNoy Ashkenazy0J. Daniel Diaz1Eric D. Hansen2J. William Harbou3Zelia M. Correa4Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USABascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USABascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA; John A. Moran Eye Institute, University of Utah, Salt Lake City, UT, USABascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA; University of Texas Southwestern Medical Center, Dallas, TX, USABascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA; Corresponding author. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 N.W. 17th Street, Miami, FL, 33136, USA.Purpose: To illustrate the diagnosis and management of an atypical, cyst-like recurrence of retinoblastoma. Observations: A 4-month-old boy was diagnosed with Group B retinoblastoma in the right eye, consisting of a 10 x 9 × 3.6 mm retinal tumor temporal to the macula. He was treated with one session of intra-arterial ophthalmic artery chemotherapy using melphalan, followed by three sessions of diode laser transpupillary thermotherapy (TTT), after which complete tumor regression was achieved. 45 weeks after initial treatment, a cystic lesion was detected adjacent to superior margin of the regressed tumor scar. The differential diagnosis included pigment epithelial detachment, retinal gliosis, secondary retinoschisis, and local tumor recurrence. Multimodal imaging including OCT angiography confirmed the diagnosis of local recurrence manifesting as a vascularized cyst-like lesion. Two additional sessions of TTT achieved sustained tumor regression through 16 months of additional follow-up. Conclusions and Importance: Recurrence of retinoblastoma following chemotherapy typically manifests as enlargement of a previously regressed tumor, or seeding into the vitreous or subretinal space. An unusual cyst-like recurrence of retinoblastoma at the margin of a previously regressed tumor was diagnosed by multimodal imaging. Focal diode laser transpupillary thermotherapy was curative.http://www.sciencedirect.com/science/article/pii/S2451993622004248RetinoblastomaIntra-arterial chemotherapyOptical coherence tomographyFluorescein angiographyTranspupillary thermotherapy |
| spellingShingle | Noy Ashkenazy J. Daniel Diaz Eric D. Hansen J. William Harbou Zelia M. Correa Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging American Journal of Ophthalmology Case Reports Retinoblastoma Intra-arterial chemotherapy Optical coherence tomography Fluorescein angiography Transpupillary thermotherapy |
| title | Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging |
| title_full | Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging |
| title_fullStr | Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging |
| title_full_unstemmed | Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging |
| title_short | Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging |
| title_sort | cyst like recurrence of retinoblastoma diagnosed by multimodal imaging |
| topic | Retinoblastoma Intra-arterial chemotherapy Optical coherence tomography Fluorescein angiography Transpupillary thermotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622004248 |
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