HIV Drug-resistant Strains as Epidemiologic Sentinels
Observed declines in drug resistance to nucleoside reverse transcriptase inhibitors among persons recently infected with HIV-1 in monitored subpopulations can be interpreted as a positive sign and lead public health officials to decrease efforts towards HIV prevention. By means of a mathematical mod...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2006-02-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/12/2/05-0321_article |
| _version_ | 1818240146244370432 |
|---|---|
| author | María S. Sánchez Robert M. Grant Travis C. Porco Wayne M. Getz |
| author_facet | María S. Sánchez Robert M. Grant Travis C. Porco Wayne M. Getz |
| author_sort | María S. Sánchez |
| collection | DOAJ |
| description | Observed declines in drug resistance to nucleoside reverse transcriptase inhibitors among persons recently infected with HIV-1 in monitored subpopulations can be interpreted as a positive sign and lead public health officials to decrease efforts towards HIV prevention. By means of a mathematical model, we identified 3 processes that can account for the observed decline: increase in high-risk behavior, decrease in proportion of acutely infected persons whose conditions are treated, and change in treatment efficacy. These processes, singly or in combination, can lead to increases or decreases in disease and drug-resistance prevalence in the general population. We discuss the most appropriate public health response under each scenario and emphasize how further data collection and analyses are required to more reliably evaluate the observed time trends and the relative importance of forces shaping the epidemic. Our study highlights how drug resistance markers can be used as epidemiologic sentinels to devise public health solutions. |
| first_indexed | 2024-12-12T13:08:48Z |
| format | Article |
| id | doaj.art-cf2da7ea3c7d4e1f8abb878ba4f93f58 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T13:08:48Z |
| publishDate | 2006-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-cf2da7ea3c7d4e1f8abb878ba4f93f582022-12-22T00:23:35ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-02-0112219119710.3201/eid1202.050321HIV Drug-resistant Strains as Epidemiologic SentinelsMaría S. SánchezRobert M. GrantTravis C. PorcoWayne M. GetzObserved declines in drug resistance to nucleoside reverse transcriptase inhibitors among persons recently infected with HIV-1 in monitored subpopulations can be interpreted as a positive sign and lead public health officials to decrease efforts towards HIV prevention. By means of a mathematical model, we identified 3 processes that can account for the observed decline: increase in high-risk behavior, decrease in proportion of acutely infected persons whose conditions are treated, and change in treatment efficacy. These processes, singly or in combination, can lead to increases or decreases in disease and drug-resistance prevalence in the general population. We discuss the most appropriate public health response under each scenario and emphasize how further data collection and analyses are required to more reliably evaluate the observed time trends and the relative importance of forces shaping the epidemic. Our study highlights how drug resistance markers can be used as epidemiologic sentinels to devise public health solutions.https://wwwnc.cdc.gov/eid/article/12/2/05-0321_articleacute infectiondrug resistanceepidemiologyHIVinfectious diseasemathematical model |
| spellingShingle | María S. Sánchez Robert M. Grant Travis C. Porco Wayne M. Getz HIV Drug-resistant Strains as Epidemiologic Sentinels Emerging Infectious Diseases acute infection drug resistance epidemiology HIV infectious disease mathematical model |
| title | HIV Drug-resistant Strains as Epidemiologic Sentinels |
| title_full | HIV Drug-resistant Strains as Epidemiologic Sentinels |
| title_fullStr | HIV Drug-resistant Strains as Epidemiologic Sentinels |
| title_full_unstemmed | HIV Drug-resistant Strains as Epidemiologic Sentinels |
| title_short | HIV Drug-resistant Strains as Epidemiologic Sentinels |
| title_sort | hiv drug resistant strains as epidemiologic sentinels |
| topic | acute infection drug resistance epidemiology HIV infectious disease mathematical model |
| url | https://wwwnc.cdc.gov/eid/article/12/2/05-0321_article |
| work_keys_str_mv | AT mariassanchez hivdrugresistantstrainsasepidemiologicsentinels AT robertmgrant hivdrugresistantstrainsasepidemiologicsentinels AT traviscporco hivdrugresistantstrainsasepidemiologicsentinels AT waynemgetz hivdrugresistantstrainsasepidemiologicsentinels |