Potential Mechanism of Action of Cyclosporin A in Human Dermal Fibroblasts—Transcriptomic Analysis of CYPs

Potential Mechanism of Action of Cyclosporin A in Human Dermal Fibroblasts—Transcriptomic Analysis of CYPs

Effect of cyclosporin A (CsA) in a therapeutic concentration, on the expression of cytochrome P450 genes (CYPs), was investigated in normal human dermal fibroblast cells. The expression of 57 genes, encoding cytochrome P450 isoforms, was estimated using the microarray method. Amongst 396 normalized...

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Bibliographic Details
Main Authors: Grażyna Janikowska, Alina Pyka-Pająk, Tomasz Janikowski, Jolanta Adamska, Urszula Mazurek, Przemysław Jędrusik
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
cyclosporin A
cytochrome P450 gene
fibroblasts
microarray
MTT test
SOFM
Online Access:http://www.mdpi.com/1420-3049/23/7/1642

Internet

http://www.mdpi.com/1420-3049/23/7/1642

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